What genes are in the Synthesis, secretion, and deacylation of Ghrelin pathway?

The Synthesis, secretion, and deacylation of Ghrelin pathway involves 4 genes. Key genes include: ACHE, BCHE, INS, PLA2G7.

Synthesis, secretion, and deacylation of Ghrelin

Q: What compounds affect the Synthesis, secretion, and deacylation of Ghrelin pathway?

92 compounds in the BiohacksAI corpus have documented interactions with genes in the Synthesis, secretion, and deacylation of Ghrelin pathway (Reactome ID: R-HSA-422085). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4220854 genes92 compounds

The Synthesis, secretion, and deacylation of Ghrelin pathway (Reactome ID: R-HSA-422085) involves 4 genes and is affected by 92 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACHE BCHE INS PLA2G7

Compounds Affecting Synthesis, secretion, and deacylation of Ghrelin

#	Compound	Targets Hit	Studies
1	Physostigmine	—	300
2	Physostigmine	—	299
3	Metergoline	—	144
4	Berberine	—	300
5	ethopropazine	—	17
6	Hexachlorophene	—	300
7	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
8	Aripiprazole	—	298
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Reserpine	—	297
11	bis(12)-hupyridone [Supplementary Concept]	—	300
12	Methylene Blue	—	200
13	Ranitidine	—	299
14	Chlorhexidine	—	299
15	Ethidium	—	300
16	Nicergoline	—	300
17	Progesterone	—	299
18	Phenylglyoxal	—	300
19	Procainamide	—	297
20	Tilorone	—	300
21	Acetaldehyde	—	300
22	Carbaryl	—	300
23	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
24	Dihydroergotamine	—	299
25	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	—	298
26	Methysergide	—	300
27	Promethazine	—	121
28	Thioridazine	—	35
29	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
30	Caffeine	—	299
31	Amisulpride	—	298
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Hyoscyamine	—	296
34	Dinitrochlorobenzene	—	300
35	Disulfiram	—	297
36	Edaravone	—	298
37	Methoxsalen	—	300
38	pirenperone	—	22
39	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
40	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	—	298
41	caffeic acid	—	300
42	fisetin	—	78
43	Fluoxetine	—	1,000
44	Quercetin	—	300
45	Rutin	—	300
46	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
47	Benzyl Alcohol	—	300
48	Bromocriptine	—	299
49	Cabergoline	—	299
50	Cilostazol	—	297

About the Synthesis, secretion, and deacylation of Ghrelin Pathway

The Synthesis, secretion, and deacylation of Ghrelin pathway is catalogued in Reactome (ID: R-HSA-422085) and involves 4 genes. In the BiohacksAI corpus, 92 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACHE, BCHE, INS, PLA2G7.