What compounds affect the SLC-mediated transmembrane transport pathway?

257 compounds in the BiohacksAI corpus have documented interactions with genes in the SLC-mediated transmembrane transport pathway (Reactome ID: R-HSA-425407). These compounds target 61 genes within this pathway.

What genes are in the SLC-mediated transmembrane transport pathway?

The SLC-mediated transmembrane transport pathway involves 61 genes. Key genes include: RUNX1, SLC12A1, SLC12A2, SLC12A3, SLC12A5, SLC15A1, SLC15A3, SLC15A4, SLC17A5, SLC1A1.

SLC-mediated transmembrane transport

REACTOME PATHWAY

Reactome: R-HSA-42540761 genes257 compounds

The SLC-mediated transmembrane transport pathway (Reactome ID: R-HSA-425407) involves 61 genes and is affected by 257 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

RUNX1 SLC12A1 SLC12A2 SLC12A3 SLC12A5 SLC15A1 SLC15A3 SLC15A4 SLC17A5 SLC1A1 SLC1A2 SLC1A3 SLC22A1 SLC22A11 SLC22A12 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC24A2 SLC24A4 SLC26A4 SLC28A1 SLC28A2 SLC28A3 SLC29A1 SLC29A4 SLC2A1+31 more

Compounds Affecting SLC-mediated transmembrane transport

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	pentamidine	—	299
3	Dinoprost	—	252
4	Dinoprostone	—	296
5	Ritonavir	—	298
6	Triiodothyronine	—	300
7	Adenosine	—	298
8	Fluoxetine	—	1,000
9	Sertraline	—	1,000
10	Carvedilol	—	296
11	Crizotinib	—	298
12	Hexachlorophene	—	300
13	Indomethacin	—	297
14	lidoflazine	—	278
15	Quinidine	—	298
16	Rifamycins	—	300
17	Rifamycins	—	300
18	Genistein	—	300
19	Thyroxine	—	994
20	Thyroxine	—	300
21	Bumetanide	—	299
22	Glucose	—	294
23	phlorhizin	—	224
24	Duloxetine Hydrochloride	—	993
25	Venlafaxine Hydrochloride	—	1,000
26	Digoxin	—	299
27	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
28	Aripiprazole	—	298
29	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
30	Ethinyl Estradiol	—	300
31	Simvastatin	—	1,000
32	Amoxapine	—	259
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Benzydamine	—	298
35	Canagliflozin	—	295
36	Chlorpheniramine	—	298
37	cinacalcet	—	298
38	Cinnarizine	—	299
39	Dequalinium	—	136
40	Flunarizine Flunarizine is	—	299
41	Fluspirilene	—	74
42	Metergoline	—	144
43	Nebivolol	—	297
44	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	—	299
45	Nortriptyline	—	295
46	oxatomide [Supplementary Concept] structure;	—	128
47	Oxyfedrine	—	144
48	Phenelzine	—	297
49	Thiethylperazine	—	165
50	Ritodrine	—	87

About the SLC-mediated transmembrane transport Pathway

The SLC-mediated transmembrane transport pathway is catalogued in Reactome (ID: R-HSA-425407) and involves 61 genes. In the BiohacksAI corpus, 257 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include RUNX1, SLC12A1, SLC12A2, SLC12A3, SLC12A5.