CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

Q: What compounds affect the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling pathway?

89 compounds in the BiohacksAI corpus have documented interactions with genes in the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling pathway (Reactome ID: R-HSA-442742). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-44274212 genes89 compounds

The CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling pathway (Reactome ID: R-HSA-442742) involves 12 genes and is affected by 89 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D CREB1 GRIN1 GRIN2B MAPK1 MAPK3 PDPK1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6

Compounds Affecting CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Sorafenib	—	300
3	alsterpaullone	—	12
4	fisetin	—	78
5	Ethidium	—	300
6	kenpaullone	—	8
7	trequinsin hydrochloride	—	1
8	Quercetin	—	300
9	plumbagin [Supplementary Concept]	—	300
10	pd98059	—	7
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	trametinib	—	296
13	withaferin	—	300
14	Glutamic Acid	—	297
15	Glutamic Acid	—	300
16	Glycine	—	300
17	pentamidine	—	299
18	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
19	Dextrorphan Dextro form of levorphanol. It acts as	—	300
20	Levorphanol	—	297
21	cycloserine	—	298
22	Aspartic Acid	—	300
23	eliprodil	—	33
24	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
25	D-Aspartic Acid	—	29
26	Dextrothyroxine	—	134
27	Dizocilpine Maleate	—	300
28	Ibotenic Acid	—	300
29	Spermine	—	300
30	hydroxyfasudil [Supplementary Concept]	—	11
31	pictilisib	—	25
32	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
33	cycloheximide	—	300
34	Disulfiram	—	297
35	Azacitidine	—	298
36	Azacitidine	—	300
37	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
38	Levalbuterol	—	1,000
39	Adenosine Monophosphate Adenine nucleotide containing	—	300
40	Levalbuterol	—	297
41	Bortezomib	—	300
42	Clofarabine	—	298
43	Dactinomycin	—	297
44	Danazol	—	298
45	Emetine	—	298
46	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
47	Sulbactam	—	299
48	chrysin	—	300
49	Genistein	—	300
50	Testosterone	—	299

About the CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Pathway

The CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling pathway is catalogued in Reactome (ID: R-HSA-442742) and involves 12 genes. In the BiohacksAI corpus, 89 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, CREB1, GRIN1, GRIN2B.