What compounds affect the Cell junction organization pathway?

145 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell junction organization pathway (Reactome ID: R-HSA-446728). These compounds target 57 genes within this pathway.

What genes are in the Cell junction organization pathway?

The Cell junction organization pathway involves 57 genes. Key genes include: ADRM1, AGO2, CSNK2A1, CSNK2A2, CSNK2A3, CSNK2B, CTBP1, CTSL, EED, EZH2.

Cell junction organization

REACTOME PATHWAY

Reactome: R-HSA-44672857 genes145 compounds

The Cell junction organization pathway (Reactome ID: R-HSA-446728) involves 57 genes and is affected by 145 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 CSNK2A1 CSNK2A2 CSNK2A3 CSNK2B CTBP1 CTSL EED EZH2 FURIN FYN GANAB HDAC1 HDAC2 KDM1A KMT5A MAPK1 MAPK3 MDM2 MPHOSPH8 MYC PKM PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7+27 more

Compounds Affecting Cell junction organization

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	fisetin	—	78
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	kenpaullone	—	8
9	Sorafenib	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	chrysin	—	300
12	alsterpaullone	—	12
13	Kaempferols	—	300
14	Vanillic Acid	—	300
15	Niclosamide	—	299
16	Ursolic Acid	—	300
17	sp600125	—	117
18	Vorinostat	—	299
19	pd98059	—	7
20	tyrphostin ag 1478	—	4
21	ly294002	—	11
22	pictilisib	—	25
23	Dasatinib	—	299
24	Crizotinib	—	298
25	Calcimycin	—	216
26	Astemizole Antihistamine drug now withdrawn from	—	280
27	Fluspirilene	—	74
28	tyrphostin 9	—	2
29	Methotrexate	—	289
30	Thioridazine	—	35
31	daph	—	2
32	Disulfiram	—	297
33	trequinsin hydrochloride	—	1
34	plumbagin [Supplementary Concept]	—	300
35	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
36	trametinib	—	296
37	withaferin	—	300
38	Axitinib	—	298
39	egcg	—	300
40	Genistein	—	300
41	Resveratrol	—	298
42	Suramin	—	300
43	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
44	scriptaid	—	53
45	Valproic Acid	—	296
46	Butyric Acid	—	300
47	Celecoxib	—	295
48	Daunorubicin	—	298
49	Camptothecin	—	300
50	Digoxin	—	299

About the Cell junction organization Pathway

The Cell junction organization pathway is catalogued in Reactome (ID: R-HSA-446728) and involves 57 genes. In the BiohacksAI corpus, 145 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, CSNK2A1, CSNK2A2, CSNK2A3.