Transcriptional regulation of pluripotent stem cells

Q: What compounds affect the Transcriptional regulation of pluripotent stem cells pathway?

79 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional regulation of pluripotent stem cells pathway (Reactome ID: R-HSA-452723). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4527236 genes79 compounds

The Transcriptional regulation of pluripotent stem cells pathway (Reactome ID: R-HSA-452723) involves 6 genes and is affected by 79 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EPAS1 EPHA1 LIN28A NR5A1 SMAD2 STAT3

Compounds Affecting Transcriptional regulation of pluripotent stem cells

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Azacitidine	—	298
3	Azacitidine	—	300
4	Ethidium	—	300
5	Podophyllotoxin	—	14
6	vinblastine sulfate	—	81
7	Bortezomib	—	300
8	Celecoxib	—	295
9	Cladribine	—	297
10	Emetine	—	298
11	Oxyphenbutazone	—	300
12	Anisomycin	—	247
13	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
15	Digoxin	—	299
16	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
17	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
18	Tubercidin	—	300
19	Disulfiram	—	297
20	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
21	Kaempferols	—	300
22	Quercetin	—	300
23	Colchicine	—	300
24	Dactinomycin	—	297
25	Danazol	—	298
26	Flutamide	—	298
27	Loratadine	—	296
28	Nisoldipine	—	297
29	chrysin	—	300
30	egcg	—	300
31	Fluoxetine	—	1,000
32	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Ciclopirox	—	88
35	Dasatinib	—	299
36	Daunorubicin	—	298
37	Dinitrochlorobenzene	—	300
38	Domperidone	—	299
39	Equilin	—	216
40	Ethinyl Estradiol	—	300
41	Ezetimibe	—	296
42	Idazoxan	—	300
43	Lynestrenol	—	299
44	Nocodazole Nocodazole is	—	215
45	Masoprocol	—	300
46	o-Phthalaldehyde	—	300
47	Perphenazine	—	297
48	pivampicillin	—	275
49	Promethazine	—	121
50	Rotenone	—	300

About the Transcriptional regulation of pluripotent stem cells Pathway

The Transcriptional regulation of pluripotent stem cells pathway is catalogued in Reactome (ID: R-HSA-452723) and involves 6 genes. In the BiohacksAI corpus, 79 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EPAS1, EPHA1, LIN28A, NR5A1, SMAD2.