What compounds affect the Signaling by EGFRvIII in Cancer pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by EGFRvIII in Cancer pathway (Reactome ID: R-HSA-5637812). These compounds target 5 genes within this pathway.

What genes are in the Signaling by EGFRvIII in Cancer pathway?

The Signaling by EGFRvIII in Cancer pathway involves 5 genes. Key genes include: CDC37, EGFR, GRB2, HSP90AA1, PIK3R1.

Signaling by EGFRvIII in Cancer

REACTOME PATHWAY

Reactome: R-HSA-56378125 genes40 compounds

The Signaling by EGFRvIII in Cancer pathway (Reactome ID: R-HSA-5637812) involves 5 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 EGFR GRB2 HSP90AA1 PIK3R1

Compounds Affecting Signaling by EGFRvIII in Cancer

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	Quercetin	—	300
4	ag490	—	14
5	Wortmannin	—	300
6	triolimus [Supplementary Concept]	—	33
7	monorden	—	8
8	gedunin	—	54
9	Novobiocin	—	300
10	caffeic acid	—	300
11	Masoprocol	—	300
12	Tetracycline	—	300
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	2-Chloroadenosine 2-Chloroadenosine.	—	300
16	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
17	Calcimycin	—	216
18	Calcitriol	—	300
19	Ciclopirox	—	88
20	Clotrimazole	—	296
21	cycloheximide	—	300
22	deguelin [Supplementary Concept]	—	151
23	Disulfiram	—	297
24	Hexachlorophene	—	300
25	Idarubicin	—	299
26	Indazoles	—	300
27	Miconazole	—	298
28	piceatannol	—	300
29	Nitroprusside	—	299
30	specioside	—	6
31	pictilisib	—	25
32	ly294002	—	11
33	alpelisib	—	227
34	Sirolimus	—	300
35	torin 1	—	10
36	Dasatinib	—	299
37	Afatinib	—	297
38	tyrphostin ag 1478	—	4
39	tyrphostin 1	—	1
40	Dactinomycin	—	297

About the Signaling by EGFRvIII in Cancer Pathway

The Signaling by EGFRvIII in Cancer pathway is catalogued in Reactome (ID: R-HSA-5637812) and involves 5 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, EGFR, GRB2, HSP90AA1, PIK3R1.