What compounds affect the Inflammasomes pathway?

102 compounds in the BiohacksAI corpus have documented interactions with genes in the Inflammasomes pathway (Reactome ID: R-HSA-622312). These compounds target 11 genes within this pathway.

What genes are in the Inflammasomes pathway?

The Inflammasomes pathway involves 11 genes. Key genes include: APP, BCL2L1, CASP1, HSP90AB1, NFKB1, NFKB2, NLRP1, NLRP3, P2RX7, PANX1.

Inflammasomes

REACTOME PATHWAY

Reactome: R-HSA-62231211 genes102 compounds

The Inflammasomes pathway (Reactome ID: R-HSA-622312) involves 11 genes and is affected by 102 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BCL2L1 CASP1 HSP90AB1 NFKB1 NFKB2 NLRP1 NLRP3 P2RX7 PANX1 RELA

Compounds Affecting Inflammasomes

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Disulfiram	—	297
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Kaempferols	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Hexachlorophene	—	300
9	Podophyllotoxin	—	14
10	Rutin	—	300
11	Withania	—	500
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	Trifluridine	—	295
15	withaferin	—	300
16	Ethinyl Estradiol	—	300
17	Thioridazine	—	35
18	egcg	—	300
19	streptonigrin	—	299
20	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
21	caffeic acid	—	300
22	vinblastine sulfate	—	81
23	Masoprocol	—	300
24	Tetracycline	—	300
25	Norethynodrel	—	299
26	Hydrocortisone	—	299
27	Cerulenin	—	300
28	Chlorpropamide	—	300
29	daph	—	2
30	Hydrocortisone	—	298
31	Lovastatin	—	300
32	ly294002	—	11
33	Promethazine	—	121
34	protriptyline	—	296
35	Sulfaphenazole	—	300
36	Triamcinolone	—	300
37	tyrphostin 1	—	1
38	tyrphostin ag 1478	—	4
39	Hesperidin	—	300
40	Methylene Blue	—	200
41	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
42	Vitamin	—	295
43	2-Methoxyestradiol	—	300
44	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
45	Cladribine	—	297
46	Digitoxin	—	300
47	Digoxin	—	299
48	Edetic Acid	—	24
49	Catechin	—	300
50	Vanillic Acid	—	300

About the Inflammasomes Pathway

The Inflammasomes pathway is catalogued in Reactome (ID: R-HSA-622312) and involves 11 genes. In the BiohacksAI corpus, 102 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L1, CASP1, HSP90AB1, NFKB1.