What compounds affect the Assembly of the pre-replicative complex pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Assembly of the pre-replicative complex pathway (Reactome ID: R-HSA-68867). These compounds target 34 genes within this pathway.

What genes are in the Assembly of the pre-replicative complex pathway?

The Assembly of the pre-replicative complex pathway involves 34 genes. Key genes include: ADRM1, GMNN, KPNB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7.

Assembly of the pre-replicative complex

REACTOME PATHWAY

Reactome: R-HSA-6886734 genes71 compounds

The Assembly of the pre-replicative complex pathway (Reactome ID: R-HSA-68867) involves 34 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 GMNN KPNB1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3+4 more

Compounds Affecting Assembly of the pre-replicative complex

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Disulfiram	—	297
4	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
5	Colchicine	—	300
6	Rotenone	—	300
7	2-Methoxyestradiol	—	300
8	Nocodazole Nocodazole is	—	215
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Metergoline	—	144
11	Podophyllotoxin	—	14
12	triflupromazine hydrochloride	—	12
13	Vorinostat	—	299
14	Calcimycin	—	216
15	Dasatinib	—	299
16	Digitoxin	—	300
17	Doxazosin	—	24
18	Ethinyl Estradiol	—	300
19	Hexachlorophene	—	300
20	kenpaullone	—	8
21	Niclosamide	—	299
22	Duloxetine Hydrochloride	—	993
23	Oleic Acid	—	112
24	ag490	—	14
25	Azacitidine	—	298
26	Azacitidine	—	300
27	Calcifediol	—	300
28	Calcitriol	—	300
29	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
30	cinacalcet	—	298
31	Clotrimazole	—	296
32	Decitabine	—	298
33	Desogestrel	—	299
34	Dibucaine	—	299
35	Digoxin	—	299
36	Ethylestrenol	—	70
37	Ethylmaleimide	—	300
38	Feprazone	—	63
39	Flunarizine Flunarizine is	—	299
40	Flunarizine Flunarizine is	—	14
41	Fluspirilene	—	74
42	gedunin	—	54
43	Idazoxan	—	300
44	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
45	Loratadine	—	296
46	Methyldopa	—	297
47	Nisoldipine	—	297
48	Masoprocol	—	300
49	Ouabain	—	300
50	paxilline	—	42

About the Assembly of the pre-replicative complex Pathway

The Assembly of the pre-replicative complex pathway is catalogued in Reactome (ID: R-HSA-68867) and involves 34 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, GMNN, KPNB1, PSMA1, PSMA2.