What compounds affect the DNA Replication Pre-Initiation pathway?

75 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Replication Pre-Initiation pathway (Reactome ID: R-HSA-69002). These compounds target 36 genes within this pathway.

What genes are in the DNA Replication Pre-Initiation pathway?

The DNA Replication Pre-Initiation pathway involves 36 genes. Key genes include: ADRM1, CDC7, CDK2, GMNN, KPNB1, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5.

DNA Replication Pre-Initiation

REACTOME PATHWAY

Reactome: R-HSA-6900236 genes75 compounds

The DNA Replication Pre-Initiation pathway (Reactome ID: R-HSA-69002) involves 36 genes and is affected by 75 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CDC7 CDK2 GMNN KPNB1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14+6 more

Compounds Affecting DNA Replication Pre-Initiation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	Disulfiram	—	297
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	alsterpaullone	—	12
7	sp600125	—	117
8	Colchicine	—	300
9	Rotenone	—	300
10	2-Methoxyestradiol	—	300
11	Nocodazole Nocodazole is	—	215
12	Astemizole Antihistamine drug now withdrawn from	—	280
13	Metergoline	—	144
14	Podophyllotoxin	—	14
15	triflupromazine hydrochloride	—	12
16	Vorinostat	—	299
17	Calcimycin	—	216
18	Dasatinib	—	299
19	Digitoxin	—	300
20	Doxazosin	—	24
21	Ethinyl Estradiol	—	300
22	Hexachlorophene	—	300
23	Niclosamide	—	299
24	Duloxetine Hydrochloride	—	993
25	Oleic Acid	—	112
26	ag490	—	14
27	Azacitidine	—	298
28	Azacitidine	—	300
29	Calcifediol	—	300
30	Calcitriol	—	300
31	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
32	cinacalcet	—	298
33	Clotrimazole	—	296
34	Decitabine	—	298
35	Desogestrel	—	299
36	Dibucaine	—	299
37	Digoxin	—	299
38	Ethylestrenol	—	70
39	Ethylmaleimide	—	300
40	Feprazone	—	63
41	Flunarizine Flunarizine is	—	299
42	Flunarizine Flunarizine is	—	14
43	Fluspirilene	—	74
44	gedunin	—	54
45	Idazoxan	—	300
46	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
47	Loratadine	—	296
48	Methyldopa	—	297
49	Nisoldipine	—	297
50	Masoprocol	—	300

About the DNA Replication Pre-Initiation Pathway

The DNA Replication Pre-Initiation pathway is catalogued in Reactome (ID: R-HSA-69002) and involves 36 genes. In the BiohacksAI corpus, 75 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CDC7, CDK2, GMNN, KPNB1.