What compounds affect the p53-Dependent G1/S DNA damage checkpoint pathway?

182 compounds in the BiohacksAI corpus have documented interactions with genes in the p53-Dependent G1/S DNA damage checkpoint pathway (Reactome ID: R-HSA-69580). These compounds target 40 genes within this pathway.

What genes are in the p53-Dependent G1/S DNA damage checkpoint pathway?

The p53-Dependent G1/S DNA damage checkpoint pathway involves 40 genes. Key genes include: ADRM1, ATM, CCNA1, CCNE2, CDK2, CHEK2, MDM2, MDM4, PSMA1, PSMA2.

p53-Dependent G1/S DNA damage checkpoint

REACTOME PATHWAY

Reactome: R-HSA-6958040 genes182 compounds

The p53-Dependent G1/S DNA damage checkpoint pathway (Reactome ID: R-HSA-69580) involves 40 genes and is affected by 182 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM CCNA1 CCNE2 CDK2 CHEK2 MDM2 MDM4 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+10 more

Compounds Affecting p53-Dependent G1/S DNA damage checkpoint

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	sp600125	—	117
4	Methylene Blue	—	200
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	Hexachlorophene	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Cladribine	—	297
11	Cytarabine	—	297
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Melphalan	—	300
14	Niclosamide	—	299
15	Methotrexate	—	289
16	Trifluridine	—	295
17	Ciclopirox	—	88
18	cycloheximide	—	300
19	Dinitrochlorobenzene	—	300
20	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
21	Vorinostat	—	299
22	Spironolactone	—	298
23	Thioridazine	—	35
24	vinblastine sulfate	—	81
25	Digoxin	—	299
26	Nisoldipine	—	297
27	Nocodazole Nocodazole is	—	215
28	Oxyphenbutazone	—	300
29	rafoxanide	—	172
30	Sertraline	—	1,000
31	Astemizole Antihistamine drug now withdrawn from	—	280
32	Chlorhexidine	—	299
33	Colchicine	—	300
34	Demecolcine	—	246
35	tyrphostin 9	—	2
36	streptonigrin	—	299
37	Lovastatin	—	300
38	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
39	Disulfiram	—	297
40	Quercetin	—	300
41	Genistein	—	300
42	chrysin	—	300
43	Harmaline	—	300
44	Adenosine Triphosphate	—	300
45	Nitrofurantoin	—	297
46	Calcimycin	—	216
47	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
48	Tubercidin	—	300
49	Anisomycin	—	247
50	colchine	—	2

About the p53-Dependent G1/S DNA damage checkpoint Pathway

The p53-Dependent G1/S DNA damage checkpoint pathway is catalogued in Reactome (ID: R-HSA-69580) and involves 40 genes. In the BiohacksAI corpus, 182 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, CCNA1, CCNE2, CDK2.