Metabolism of carbohydrates and carbohydrate derivatives

Q: What compounds affect the Metabolism of carbohydrates and carbohydrate derivatives pathway?

82 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of carbohydrates and carbohydrate derivatives pathway (Reactome ID: R-HSA-71387). These compounds target 31 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-7138731 genes82 compounds

The Metabolism of carbohydrates and carbohydrate derivatives pathway (Reactome ID: R-HSA-71387) involves 31 genes and is affected by 82 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCC5 AGL ALDH1A1 CTSL FBP1 FUT6 FUT7 G6PD GAA GALK1 GALNS GAPDH GCK GCKR HK2 HKDC1 HPSE MAN2B1 PGAM1 PGD PHKG1 PHKG2 PKLR PKM PPP2CA PRKACA PRKACB PRKACG PYGL SLC17A5+1 more

Compounds Affecting Metabolism of carbohydrates and carbohydrate derivatives

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	egcg	—	300
3	Aurintricarboxylic Acid	—	184
4	hydroxyfasudil [Supplementary Concept]	—	11
5	caffeic acid	—	300
6	streptonigrin	—	299
7	Catechin	—	300
8	Niclosamide	—	299
9	Suramin	—	300
10	1-Deoxynojirimycin	—	299
11	Demeclocycline	—	297
12	Disulfiram	—	297
13	Afatinib	—	297
14	Azacitidine	—	298
15	Azacitidine	—	300
16	Epinephrine	—	299
17	Berberine	—	300
18	plumbagin [Supplementary Concept]	—	300
19	Vitamin K 3	—	300
20	Catechin	—	51
21	Rosmarinic Acid	—	300
22	Vitamin K 2	—	300
23	Carbazilquinone	—	48
24	salvin [Supplementary Concept]	—	300
25	Dactinomycin	—	297
26	Dihydroxyphenylalanine	—	300
27	Ergosterol	—	300
28	Ethidium	—	300
29	Fusaric Acid	—	300
30	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
31	Lovastatin	—	300
32	Methyldopa	—	297
33	Norepinephrine Precursor of epinephrine that is secreted by	—	298
34	Oxcarbazepine	—	296
35	Pioglitazone	—	297
36	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
37	fisetin	—	78
38	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
39	alphitonin [Supplementary Concept] from	—	300
40	Sirolimus	—	300
41	Spermidine	—	241
42	pd98059	—	7
43	Pseudoephedrine	—	298
44	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
45	Rutin	—	300
46	amlexanox	—	96
47	Carbaryl	—	300
48	Doxazosin	—	24
49	4-Hydroxybenzoate-3-Monooxygenase	—	300
50	Genistein	—	300

About the Metabolism of carbohydrates and carbohydrate derivatives Pathway

The Metabolism of carbohydrates and carbohydrate derivatives pathway is catalogued in Reactome (ID: R-HSA-71387) and involves 31 genes. In the BiohacksAI corpus, 82 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC5, AGL, ALDH1A1, CTSL, FBP1.