What genes are in the RNA Polymerase I Transcription Initiation pathway?

The RNA Polymerase I Transcription Initiation pathway involves 7 genes. Key genes include: CDK7, EHMT2, ERCC3, HDAC1, HDAC2, KAT2A, KAT2B.

RNA Polymerase I Transcription Initiation

Q: What compounds affect the RNA Polymerase I Transcription Initiation pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the RNA Polymerase I Transcription Initiation pathway (Reactome ID: R-HSA-73762). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-737627 genes45 compounds

The RNA Polymerase I Transcription Initiation pathway (Reactome ID: R-HSA-73762) involves 7 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 EHMT2 ERCC3 HDAC1 HDAC2 KAT2A KAT2B

Compounds Affecting RNA Polymerase I Transcription Initiation

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Vorinostat	—	299
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	scriptaid	—	53
5	Valproic Acid	—	296
6	Butyric Acid	—	300
7	Ursolic Acid	—	300
8	Celecoxib	—	295
9	Daunorubicin	—	298
10	Bortezomib	—	300
11	Camptothecin	—	300
12	Aurintricarboxylic Acid	—	184
13	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
14	DEAD-box RNA Helicases	—	169
15	Thioctic Acid	—	298
16	Arachidonic Acid	—	245
17	Oleic Acid	—	112
18	alpha-Linolenic Acid	—	300
19	candesartan cilexetil [Supplementary Concept]	—	300
20	Cisplatin	—	300
21	diallyl trisulfide	—	246
22	Estramustine	—	300
23	gamma-Linolenic Acid	—	300
24	Hexachlorophene	—	300
25	Iodoacetamide	—	300
26	Lithocholic Acid	—	300
27	Oxytetracycline	—	300
28	rafoxanide	—	172
29	Ritonavir	—	298
30	Thioctic Acid	—	300
31	Trazodone	—	297
32	Disulfiram	—	297
33	s adenosylhomocysteine	—	300
34	Cyproheptadine	—	299
35	Gliotoxin	—	300
36	Glutathione	—	300
37	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
38	Dimethyl Sulfoxide	—	300
39	ninhydrin	—	300
40	np1	—	81
41	egcg	—	300
42	plumbagin [Supplementary Concept]	—	300
43	hydroxyfasudil [Supplementary Concept]	—	11
44	Sorafenib	—	300
45	Tripterygium	—	300

About the RNA Polymerase I Transcription Initiation Pathway

The RNA Polymerase I Transcription Initiation pathway is catalogued in Reactome (ID: R-HSA-73762) and involves 7 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, EHMT2, ERCC3, HDAC1, HDAC2.