What compounds affect the RNA Polymerase I Transcription pathway?

63 compounds in the BiohacksAI corpus have documented interactions with genes in the RNA Polymerase I Transcription pathway (Reactome ID: R-HSA-73864). These compounds target 9 genes within this pathway.

What genes are in the RNA Polymerase I Transcription pathway?

The RNA Polymerase I Transcription pathway involves 9 genes. Key genes include: CDK7, EHMT2, ERCC3, HDAC1, HDAC2, KAT2A, KAT2B, MAPK3, MBD2.

RNA Polymerase I Transcription

REACTOME PATHWAY

Reactome: R-HSA-738649 genes63 compounds

The RNA Polymerase I Transcription pathway (Reactome ID: R-HSA-73864) involves 9 genes and is affected by 63 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 EHMT2 ERCC3 HDAC1 HDAC2 KAT2A KAT2B MAPK3 MBD2

Compounds Affecting RNA Polymerase I Transcription

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	DEAD-box RNA Helicases	—	169
3	Thioctic Acid	—	298
4	Thioctic Acid	—	300
5	Vorinostat	—	299
6	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
7	scriptaid	—	53
8	Valproic Acid	—	296
9	Butyric Acid	—	300
10	Ursolic Acid	—	300
11	Celecoxib	—	295
12	Daunorubicin	—	298
13	Bortezomib	—	300
14	Camptothecin	—	300
15	plumbagin [Supplementary Concept]	—	300
16	Sorafenib	—	300
17	Aurintricarboxylic Acid	—	184
18	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
19	Arachidonic Acid	—	245
20	Oleic Acid	—	112
21	alpha-Linolenic Acid	—	300
22	candesartan cilexetil [Supplementary Concept]	—	300
23	Cisplatin	—	300
24	diallyl trisulfide	—	246
25	Estramustine	—	300
26	gamma-Linolenic Acid	—	300
27	Hexachlorophene	—	300
28	Iodoacetamide	—	300
29	Lithocholic Acid	—	300
30	Oxytetracycline	—	300
31	rafoxanide	—	172
32	Ritonavir	—	298
33	Trazodone	—	297
34	Methylene Blue	—	200
35	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
36	Cefixime	—	300
37	Ethidium	—	300
38	Levodopa	—	297
39	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
40	Demeclocycline	—	5
41	Didanosine	—	297
42	Dinitolmide	—	25
43	Edaravone	—	298
44	Ribitol	—	297
45	Xylitol	—	300
46	Disulfiram	—	297
47	s adenosylhomocysteine	—	300
48	Cyproheptadine	—	299
49	Gliotoxin	—	300
50	Glutathione	—	300

About the RNA Polymerase I Transcription Pathway

The RNA Polymerase I Transcription pathway is catalogued in Reactome (ID: R-HSA-73864) and involves 9 genes. In the BiohacksAI corpus, 63 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, EHMT2, ERCC3, HDAC1, HDAC2.