What compounds affect the Insulin receptor signalling cascade pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the Insulin receptor signalling cascade pathway (Reactome ID: R-HSA-74751). These compounds target 18 genes within this pathway.

What genes are in the Insulin receptor signalling cascade pathway?

The Insulin receptor signalling cascade pathway involves 18 genes. Key genes include: FGF22, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, GRB2, INS, INSR, MAPK1.

Insulin receptor signalling cascade

REACTOME PATHWAY

Reactome: R-HSA-7475118 genes51 compounds

The Insulin receptor signalling cascade pathway (Reactome ID: R-HSA-74751) involves 18 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 GRB2 INS INSR MAPK1 MAPK3 PDE3B PDPK1 PIK3C3 PIK3CB PIK3R1 PIK3R2 TLR9

Compounds Affecting Insulin receptor signalling cascade

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	sp600125	—	117
3	pictilisib	—	25
4	alsterpaullone	—	12
5	kenpaullone	—	8
6	Axitinib	—	298
7	Crizotinib	—	298
8	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
9	Wortmannin	—	300
10	ly294002	—	11
11	Sirolimus	—	300
12	Dasatinib	—	299
13	plumbagin [Supplementary Concept]	—	300
14	pd98059	—	7
15	tyrphostin ag 1478	—	4
16	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
17	trametinib	—	296
18	withaferin	—	300
19	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
20	Quercetin	—	300
21	alpelisib	—	227
22	torin 1	—	10
23	Clotrimazole	—	296
24	fisetin	—	78
25	Progesterone	—	299
26	2-Chloroadenosine 2-Chloroadenosine.	—	300
27	Benzalkonium Compounds	—	299
28	Calcimycin	—	216
29	daph	—	2
30	Diphenhydramine	—	14
31	ha1004	—	4
32	Lithocholic Acid	—	300
33	Loratadine	—	296
34	trequinsin hydrochloride	—	1
35	Afatinib	—	297
36	tyrphostin ag 1295	—	1
37	Kaempferols	—	300
38	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
39	Resveratrol	—	298
40	Digitoxin	—	300
41	Digoxin	—	299
42	Flutamide	—	298
43	m084	—	2
44	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
45	Cilostazol	—	297
46	Papaverine	—	299
47	Enoximone	—	300
48	Cyclic GMP Guanosine cyclic 3',5'-(hydrogen phosphate).	—	300
49	Acrylamide	—	300
50	Dactinomycin	—	297

About the Insulin receptor signalling cascade Pathway

The Insulin receptor signalling cascade pathway is catalogued in Reactome (ID: R-HSA-74751) and involves 18 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FGF22, FGFR1, FGFR2, FGFR3, FGFR4.