The role of GTSE1 in G2/M progression after G2 checkpoint

Q: What compounds affect the The role of GTSE1 in G2/M progression after G2 checkpoint pathway?

186 compounds in the BiohacksAI corpus have documented interactions with genes in the The role of GTSE1 in G2/M progression after G2 checkpoint pathway (Reactome ID: R-HSA-8852276). These compounds target 56 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-885227656 genes186 compounds

The The role of GTSE1 in G2/M progression after G2 checkpoint pathway (Reactome ID: R-HSA-8852276) involves 56 genes and is affected by 186 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNB1 CCNB2 CDK1 HSP90AA1 HSP90AB1 PLK1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+26 more

Compounds Affecting The role of GTSE1 in G2/M progression after G2 checkpoint

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Noscapine	—	300
5	Vincristine	—	299
6	Reserpine	—	297
7	Vorinostat	—	299
8	vinblastine sulfate	—	81
9	Demecolcine	—	246
10	Podophyllotoxin	—	14
11	Maytansine	—	300
12	Quercetin	—	300
13	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
14	chrysin	—	300
15	Disulfiram	—	297
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
18	Hexachlorophene	—	300
19	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
20	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
21	Clotrimazole	—	296
22	celastrol	—	300
23	Idarubicin	—	299
24	triolimus [Supplementary Concept]	—	33
25	monorden	—	8
26	kenpaullone	—	8
27	alsterpaullone	—	12
28	indirubin	—	300
29	fisetin	—	78
30	Rotenone	—	300
31	Genistein	—	300
32	Ciclopirox	—	88
33	cycloheximide	—	300
34	Clofibrate	—	299
35	Fenofibrate	—	297
36	Harmaline	—	300
37	Nisoldipine	—	297
38	Oxyphenbutazone	—	300
39	sp600125	—	117
40	Sertraline	—	1,000
41	2-Chloroadenosine 2-Chloroadenosine.	—	300
42	Cinnarizine	—	299
43	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
44	gedunin	—	54
45	Novobiocin	—	300
46	caffeic acid	—	300
47	Masoprocol	—	300
48	Tetracycline	—	300
49	ag490	—	14
50	piceatannol	—	300

About the The role of GTSE1 in G2/M progression after G2 checkpoint Pathway

The The role of GTSE1 in G2/M progression after G2 checkpoint pathway is catalogued in Reactome (ID: R-HSA-8852276) and involves 56 genes. In the BiohacksAI corpus, 186 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNB1, CCNB2, CDK1, HSP90AA1.