What compounds affect the Transcriptional Regulation by VENTX pathway?

190 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional Regulation by VENTX pathway (Reactome ID: R-HSA-8853884). These compounds target 8 genes within this pathway.

What genes are in the Transcriptional Regulation by VENTX pathway?

The Transcriptional Regulation by VENTX pathway involves 8 genes. Key genes include: CSF1R, EHMT1, EHMT2, IL6, NFKB1, RELA, TCF7L2, TP53.

Transcriptional Regulation by VENTX

REACTOME PATHWAY

Reactome: R-HSA-88538848 genes190 compounds

The Transcriptional Regulation by VENTX pathway (Reactome ID: R-HSA-8853884) involves 8 genes and is affected by 190 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSF1R EHMT1 EHMT2 IL6 NFKB1 RELA TCF7L2 TP53

Compounds Affecting Transcriptional Regulation by VENTX

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Bortezomib	—	300
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Trifluridine	—	295
5	Quercetin	—	300
6	ninhydrin	—	300
7	Resveratrol	—	298
8	withaferin	—	300
9	Hexachlorophene	—	300
10	Axitinib	—	298
11	plumbagin [Supplementary Concept]	—	300
12	daph	—	2
13	vinblastine sulfate	—	81
14	sp600125	—	117
15	Dasatinib	—	299
16	Podophyllotoxin	—	14
17	Kaempferols	—	300
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Rutin	—	300
20	Withania	—	500
21	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
22	tamarixetin	—	26
23	tyrphostin ag 1478	—	4
24	s adenosylhomocysteine	—	300
25	Glutathione	—	300
26	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
27	Dimethyl Sulfoxide	—	300
28	Ethidium	—	300
29	Ethinyl Estradiol	—	300
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Methylene Blue	—	200
33	Rotenone	—	300
34	Azathioprine	—	300
35	Cladribine	—	297
36	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
37	Cytarabine	—	297
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	Melphalan	—	300
40	Niclosamide	—	299
41	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
42	Methotrexate	—	289
43	Dactinomycin	—	297
44	Daunorubicin	—	298
45	Glutaral	—	42
46	Vitamin K 3	—	300
47	o-Phthalaldehyde	—	300
48	Razoxane	—	154
49	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
50	Camptothecin	—	300

About the Transcriptional Regulation by VENTX Pathway

The Transcriptional Regulation by VENTX pathway is catalogued in Reactome (ID: R-HSA-8853884) and involves 8 genes. In the BiohacksAI corpus, 190 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSF1R, EHMT1, EHMT2, IL6, NFKB1.