What compounds affect the Clathrin-mediated endocytosis pathway?

237 compounds in the BiohacksAI corpus have documented interactions with genes in the Clathrin-mediated endocytosis pathway (Reactome ID: R-HSA-8856828). These compounds target 18 genes within this pathway.

What genes are in the Clathrin-mediated endocytosis pathway?

The Clathrin-mediated endocytosis pathway involves 18 genes. Key genes include: AAK1, ADRB2, AGTR1, ARRB1, AVPR2, CFTR, CHRM2, COPS5, EGFR, GAK.

Clathrin-mediated endocytosis

REACTOME PATHWAY

Reactome: R-HSA-885682818 genes237 compounds

The Clathrin-mediated endocytosis pathway (Reactome ID: R-HSA-8856828) involves 18 genes and is affected by 237 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AAK1 ADRB2 AGTR1 ARRB1 AVPR2 CFTR CHRM2 COPS5 EGFR GAK GRB2 GRK2 HSPA8 NEDD8 PIK3C2A SYNJ2 TACR1 TOR1A

Compounds Affecting Clathrin-mediated endocytosis

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Disulfiram	—	297
3	Chlorhexidine	—	299
4	Carvedilol	—	296
5	Hexachlorophene	—	300
6	Astemizole Antihistamine drug now withdrawn from	—	280
7	Amoxapine	—	259
8	Axitinib	—	298
9	candesartan cilexetil [Supplementary Concept]	—	300
10	pictilisib	—	25
11	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
12	Nadolol	—	297
13	Terbutaline	—	299
14	Hydroxyzine	—	298
15	Loratadine	—	296
16	Nicergoline	—	300
17	Nisoldipine	—	297
18	Anisomycin	—	247
19	Clotrimazole	—	296
20	Dinitrochlorobenzene	—	300
21	Maprotiline	—	299
22	Promazine	—	40
23	Loxapine	—	225
24	Nortriptyline	—	295
25	Oxyphenbutazone	—	300
26	Perphenazine	—	297
27	rafoxanide	—	172
28	Tolterodine Tartrate	—	73
29	Methylene Blue	—	200
30	Hyoscyamine	—	296
31	Flurandrenolone	—	65
32	Niclosamide	—	299
33	Tilorone	—	300
34	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
35	Quercetin	—	300
36	dofetilide	—	298
37	Flunarizine Flunarizine is	—	299
38	Afatinib	—	297
39	Dasatinib	—	299
40	sp600125	—	117
41	Propranolol	—	300
42	Levalbuterol	—	1,000
43	Levalbuterol	—	297
44	Alprenolol	—	300
45	Epinephrine	—	299
46	Norepinephrine Precursor of epinephrine that is secreted by	—	298
47	Levalbuterol	—	166
48	Atenolol	—	297
49	Pindolol	—	299
50	Timolol	—	298

About the Clathrin-mediated endocytosis Pathway

The Clathrin-mediated endocytosis pathway is catalogued in Reactome (ID: R-HSA-8856828) and involves 18 genes. In the BiohacksAI corpus, 237 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AAK1, ADRB2, AGTR1, ARRB1, AVPR2.