What compounds affect the PTK6 promotes HIF1A stabilization pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the PTK6 promotes HIF1A stabilization pathway (Reactome ID: R-HSA-8857538). These compounds target 4 genes within this pathway.

What genes are in the PTK6 promotes HIF1A stabilization pathway?

The PTK6 promotes HIF1A stabilization pathway involves 4 genes. Key genes include: EGFR, HIF1A, LRRK2, PTK6.

PTK6 promotes HIF1A stabilization

REACTOME PATHWAY

Reactome: R-HSA-88575384 genes53 compounds

The PTK6 promotes HIF1A stabilization pathway (Reactome ID: R-HSA-8857538) involves 4 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EGFR HIF1A LRRK2 PTK6

Compounds Affecting PTK6 promotes HIF1A stabilization

#	Compound	Targets Hit	Studies
1	ag490	—	14
2	Dasatinib	—	299
3	Emetine	—	298
4	cycloheximide	—	300
5	Topotecan	—	300
6	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
7	Gliotoxin	—	300
8	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
9	Bortezomib	—	300
10	Harmaline	—	300
11	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
12	Loratadine	—	296
13	oxatomide [Supplementary Concept] structure;	—	128
14	triolimus [Supplementary Concept]	—	33
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	chrysin	—	300
17	Hydrocortisone	—	299
18	egcg	—	300
19	Kaempferols	—	300
20	Quercetin	—	300
21	Resveratrol	—	298
22	2-Chloroadenosine 2-Chloroadenosine.	—	300
23	Beclomethasone	—	300
24	Camptothecin	—	300
25	celastrol	—	300
26	Clotrimazole	—	296
27	cycloserine	—	298
28	Dequalinium	—	136
29	Desoximetasone	—	86
30	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
32	Digoxin	—	299
33	Epinephrine	—	299
34	Ethoxyquin Antioxidant; also	—	180
35	Fusaric Acid	—	300
36	gedunin	—	54
37	Hesperidin	—	300
38	Hydrocortisone	—	298
39	Mometasone Furoate	—	292
40	Niclosamide	—	299
41	Nisoldipine	—	297
42	Oxytetracycline	—	300
43	Phenoxybenzamine	—	21
44	sp600125	—	117
45	Tubercidin	—	300
46	tyrphostin 9	—	2
47	Afatinib	—	297
48	tyrphostin ag 1478	—	4
49	tyrphostin 1	—	1
50	Axitinib	—	298

About the PTK6 promotes HIF1A stabilization Pathway

The PTK6 promotes HIF1A stabilization pathway is catalogued in Reactome (ID: R-HSA-8857538) and involves 4 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EGFR, HIF1A, LRRK2, PTK6.