What compounds affect the Metabolism of RNA pathway?

125 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of RNA pathway (Reactome ID: R-HSA-8953854). These compounds target 71 genes within this pathway.

What genes are in the Metabolism of RNA pathway?

The Metabolism of RNA pathway involves 71 genes. Key genes include: ADRM1, APOBEC3A, CDK7, CSNK1D, CSNK1E, EIF4A1, EIF4G1, ELAVL1, ERCC3, HNRNPA1.

Metabolism of RNA

REACTOME PATHWAY

Reactome: R-HSA-895385471 genes125 compounds

The Metabolism of RNA pathway (Reactome ID: R-HSA-8953854) involves 71 genes and is affected by 125 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 APOBEC3A CDK7 CSNK1D CSNK1E EIF4A1 EIF4G1 ELAVL1 ERCC3 HNRNPA1 HSPA1A HSPA1B HSPA8 HSPB1 IGF2BP1 MAPK11 MAPK14 MAPKAPK2 METTL14 METTL3 NAT10 PABPC1 PPP1CA PPP2CA PRMT5 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5+41 more

Compounds Affecting Metabolism of RNA

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Hexachlorophene	—	300
5	egcg	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Afatinib	—	297
8	pictilisib	—	25
9	s adenosylhomocysteine	—	300
10	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
11	Adenosine Triphosphate	—	300
12	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
13	Azauridine	—	300
14	Oxytetracycline	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Sorafenib	—	300
17	Dasatinib	—	299
18	sp600125	—	117
19	Ergosterol	—	300
20	Disulfiram	—	297
21	Clotrimazole	—	296
22	Phenoxybenzamine	—	21
23	Leflunomide	—	297
24	Mometasone Furoate	—	292
25	Genistein	—	300
26	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
27	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
28	Niclosamide	—	299
29	chrysin	—	300
30	Anthralin	—	299
31	Chlorhexidine	—	299
32	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
33	Anisomycin	—	247
34	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
35	withaferin	—	300
36	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
37	same	—	299
38	s adenosylmethionine	—	300
39	Axitinib	—	298
40	Crizotinib	—	298
41	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
42	Vitamin	—	295
43	Bufotenin	—	93
44	Feprazone	—	63
45	Nocodazole Nocodazole is	—	215
46	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
47	Adapalene	—	296
48	alpha-Linolenic Acid	—	300
49	Ciclopirox	—	88
50	Danazol	—	298

About the Metabolism of RNA Pathway

The Metabolism of RNA pathway is catalogued in Reactome (ID: R-HSA-8953854) and involves 71 genes. In the BiohacksAI corpus, 125 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, APOBEC3A, CDK7, CSNK1D, CSNK1E.