What compounds affect the RHOA GTPase cycle pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOA GTPase cycle pathway (Reactome ID: R-HSA-8980692). These compounds target 12 genes within this pathway.

What genes are in the RHOA GTPase cycle pathway?

The RHOA GTPase cycle pathway involves 12 genes. Key genes include: ARHGAP35, BCR, CIT, PIK3R1, PIK3R2, PKN1, PKN2, PKN3, RACGAP1, ROCK2.

RHOA GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-898069212 genes28 compounds

The RHOA GTPase cycle pathway (Reactome ID: R-HSA-8980692) involves 12 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 BCR CIT PIK3R1 PIK3R2 PKN1 PKN2 PKN3 RACGAP1 ROCK2 SLK STK10

Compounds Affecting RHOA GTPase cycle

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Crizotinib	—	298
3	Axitinib	—	298
4	Sorafenib	—	300
5	Quercetin	—	300
6	Dasatinib	—	299
7	Afatinib	—	297
8	alsterpaullone	—	12
9	sp600125	—	117
10	pictilisib	—	25
11	ly294002	—	11
12	Sirolimus	—	300
13	kenpaullone	—	8
14	Kinetin	—	300
15	Edaravone	—	298
16	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
17	triolimus [Supplementary Concept]	—	33
18	pterostilbene	—	299
19	Imatinib Mesylate	—	300
20	Wortmannin	—	300
21	alpelisib	—	227
22	torin 1	—	10
23	Pueraria	—	300
24	Kaempferols	—	300
25	Catechin	—	300
26	Equilin	—	216
27	Hydrocortisone	—	299
28	Hydrocortisone	—	298

About the RHOA GTPase cycle Pathway

The RHOA GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-8980692) and involves 12 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, BCR, CIT, PIK3R1, PIK3R2.