What compounds affect the RHOC GTPase cycle pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOC GTPase cycle pathway (Reactome ID: R-HSA-9013106). These compounds target 12 genes within this pathway.

What genes are in the RHOC GTPase cycle pathway?

The RHOC GTPase cycle pathway involves 12 genes. Key genes include: ARHGAP35, BCR, CIT, PIK3R1, PKN1, PKN2, PKN3, RACGAP1, RHOC, ROCK2.

RHOC GTPase cycle

REACTOME PATHWAY

Reactome: R-HSA-901310612 genes29 compounds

The RHOC GTPase cycle pathway (Reactome ID: R-HSA-9013106) involves 12 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 BCR CIT PIK3R1 PKN1 PKN2 PKN3 RACGAP1 RHOC ROCK2 SLK STK10

Compounds Affecting RHOC GTPase cycle

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Crizotinib	—	298
3	Axitinib	—	298
4	Sorafenib	—	300
5	Quercetin	—	300
6	Dasatinib	—	299
7	Afatinib	—	297
8	alsterpaullone	—	12
9	sp600125	—	117
10	kenpaullone	—	8
11	Kinetin	—	300
12	Edaravone	—	298
13	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
14	triolimus [Supplementary Concept]	—	33
15	pterostilbene	—	299
16	Imatinib Mesylate	—	300
17	pictilisib	—	25
18	Wortmannin	—	300
19	ly294002	—	11
20	alpelisib	—	227
21	Sirolimus	—	300
22	torin 1	—	10
23	Pueraria	—	300
24	Kaempferols	—	300
25	Catechin	—	300
26	Equilin	—	216
27	Hydrocortisone	—	299
28	Hydrocortisone	—	298
29	Atorvastatin	—	1,000

About the RHOC GTPase cycle Pathway

The RHOC GTPase cycle pathway is catalogued in Reactome (ID: R-HSA-9013106) and involves 12 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, BCR, CIT, PIK3R1, PKN1.