What compounds affect the Signaling by ERBB2 TMD/JMD mutants pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ERBB2 TMD/JMD mutants pathway (Reactome ID: R-HSA-9665686). These compounds target 7 genes within this pathway.

What genes are in the Signaling by ERBB2 TMD/JMD mutants pathway?

The Signaling by ERBB2 TMD/JMD mutants pathway involves 7 genes. Key genes include: CDC37, EGFR, ERBB2, ERBB3, ERBB4, GRB2, HSP90AA1.

Signaling by ERBB2 TMD/JMD mutants

REACTOME PATHWAY

Reactome: R-HSA-96656867 genes36 compounds

The Signaling by ERBB2 TMD/JMD mutants pathway (Reactome ID: R-HSA-9665686) involves 7 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDC37 EGFR ERBB2 ERBB3 ERBB4 GRB2 HSP90AA1

Compounds Affecting Signaling by ERBB2 TMD/JMD mutants

#	Compound	Targets Hit	Studies
1	Afatinib	—	297
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
5	celastrol	—	300
6	ag490	—	14
7	triolimus [Supplementary Concept]	—	33
8	monorden	—	8
9	gedunin	—	54
10	Novobiocin	—	300
11	caffeic acid	—	300
12	Masoprocol	—	300
13	Tetracycline	—	300
14	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Quercetin	—	300
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
19	Calcimycin	—	216
20	Calcitriol	—	300
21	Ciclopirox	—	88
22	Clotrimazole	—	296
23	cycloheximide	—	300
24	deguelin [Supplementary Concept]	—	151
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Idarubicin	—	299
28	Indazoles	—	300
29	Miconazole	—	298
30	piceatannol	—	300
31	Nitroprusside	—	299
32	specioside	—	6
33	Wortmannin	—	300
34	tyrphostin 1	—	1
35	sp600125	—	117
36	Dactinomycin	—	297

About the Signaling by ERBB2 TMD/JMD mutants Pathway

The Signaling by ERBB2 TMD/JMD mutants pathway is catalogued in Reactome (ID: R-HSA-9665686) and involves 7 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDC37, EGFR, ERBB2, ERBB3, ERBB4.