What compounds affect the Signaling by KIT in disease pathway?

54 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by KIT in disease pathway (Reactome ID: R-HSA-9669938). These compounds target 14 genes within this pathway.

What genes are in the Signaling by KIT in disease pathway?

The Signaling by KIT in disease pathway involves 14 genes. Key genes include: FYN, GRB2, JAK2, KIT, LCK, LYN, PIK3R1, PIK3R2, PIK3R3, SRC.

Signaling by KIT in disease

REACTOME PATHWAY

Reactome: R-HSA-966993814 genes54 compounds

The Signaling by KIT in disease pathway (Reactome ID: R-HSA-9669938) involves 14 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRB2 JAK2 KIT LCK LYN PIK3R1 PIK3R2 PIK3R3 SRC STAT1 STAT3 STAT5A YES1

Compounds Affecting Signaling by KIT in disease

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Sorafenib	—	300
3	Crizotinib	—	298
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	Quercetin	—	300
7	Axitinib	—	298
8	pictilisib	—	25
9	sp600125	—	117
10	Sirolimus	—	300
11	Cladribine	—	297
12	Methylene Blue	—	200
13	streptonigrin	—	299
14	Afatinib	—	297
15	alsterpaullone	—	12
16	Niclosamide	—	299
17	Acetic Acid Product of	—	300
18	egcg	—	300
19	ly294002	—	11
20	Azauridine	—	300
21	2-Methoxyestradiol	—	300
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Azathioprine	—	300
24	Calcitriol	—	300
25	Camptothecin	—	300
26	Cytarabine	—	297
27	dihydrorotenone	—	13
28	Podophyllotoxin	—	14
29	Trifluridine	—	295
30	Tripterygium	—	300
31	Kaempferols	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Pioglitazone	—	297
34	Vemurafenib	—	298
35	Resveratrol	—	298
36	Adenosine Monophosphate Adenine nucleotide containing	—	300
37	monorden	—	8
38	piceatannol	—	300
39	Swainsonine	—	300
40	Rosmarinic Acid	—	300
41	Genistein	—	300
42	Avapritinib	—	246
43	Imatinib Mesylate	—	300
44	pd98059	—	7
45	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
46	Wortmannin	—	300
47	alpelisib	—	227
48	torin 1	—	10
49	Budesonide	—	1,000
50	Flurandrenolone	—	65

About the Signaling by KIT in disease Pathway

The Signaling by KIT in disease pathway is catalogued in Reactome (ID: R-HSA-9669938) and involves 14 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, JAK2, KIT, LCK.