B

BiohacksAI

Evidence-Based Biohacking

Patent Pending

Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

REACTOME PATHWAY
Reactome: R-HSA-967043914 genes54 compounds

The Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants pathway (Reactome ID: R-HSA-9670439) involves 14 genes and is affected by 54 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYNGRB2JAK2KITLCKLYNPIK3R1PIK3R2PIK3R3SRCSTAT1STAT3STAT5AYES1

Compounds Affecting Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants

#CompoundTargets HitStudies
1Dasatinib—299
2Sorafenib—300
3Crizotinib—298
4tyrphostin ag 1478—4
5kenpaullone—8
6Quercetin—300
7Axitinib—298
8pictilisib—25
9sp600125—117
10Sirolimus—300
11Cladribine—297
12Methylene Blue—200
13streptonigrin—299
14Afatinib—297
15alsterpaullone—12
16Niclosamide—299
17Acetic Acid Product of—300
18egcg—300
19ly294002—11
20Azauridine—300
212-Methoxyestradiol—300
22Astemizole Antihistamine drug now withdrawn from—280
23Azathioprine—300
24Calcitriol—300
25Camptothecin—300
26Cytarabine—297
27dihydrorotenone—13
28Podophyllotoxin—14
29Trifluridine—295
30Tripterygium—300
31Kaempferols—300
32Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
33Pioglitazone—297
34Vemurafenib—298
35Resveratrol—298
36Adenosine Monophosphate Adenine nucleotide containing—300
37monorden—8
38piceatannol—300
39Swainsonine—300
40Rosmarinic Acid—300
41Genistein—300
42Avapritinib—246
43Imatinib Mesylate—300
44pd98059—7
45N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]—8
46Wortmannin—300
47alpelisib—227
48torin 1—10
49Budesonide—1,000
50Flurandrenolone—65

About the Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Pathway

The Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants pathway is catalogued in Reactome (ID: R-HSA-9670439) and involves 14 genes. In the BiohacksAI corpus, 54 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, JAK2, KIT, LCK.