What compounds affect the Potential therapeutics for SARS pathway?

462 compounds in the BiohacksAI corpus have documented interactions with genes in the Potential therapeutics for SARS pathway (Reactome ID: R-HSA-9679191). These compounds target 40 genes within this pathway.

What genes are in the Potential therapeutics for SARS pathway?

The Potential therapeutics for SARS pathway involves 40 genes. Key genes include: ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3, BRD4, BTK, CHURC1-FNTB.

Potential therapeutics for SARS

REACTOME PATHWAY

Reactome: R-HSA-967919140 genes462 compounds

The Potential therapeutics for SARS pathway (Reactome ID: R-HSA-9679191) involves 40 genes and is affected by 462 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 BRD4 BTK CHURC1-FNTB CYSLTR1 FKBP1A FKBP4 FNTA FNTB FURIN FXYD2 GRB2 HDAC1 HDAC2 HSP90AA1 HSP90AB1 IMPDH1 IMPDH2 ITGA4 JAK2 JAK3 KDM1A NFE2L2 NR3C1+10 more

Compounds Affecting Potential therapeutics for SARS

#	Compound	Targets Hit	Studies
1	Digitoxin	—	300
2	Digoxin	—	299
3	Ouabain	—	300
4	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
5	Quercetin	—	300
6	Lovastatin	—	300
7	Crizotinib	—	298
8	Axitinib	—	298
9	Daunorubicin	—	298
10	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
11	sp600125	—	117
12	Vorinostat	—	299
13	Podophyllotoxin	—	14
14	Bortezomib	—	300
15	Methotrexate	—	289
16	Celecoxib	—	295
17	Clotrimazole	—	296
18	Dasatinib	—	299
19	cycloheximide	—	300
20	Astemizole Antihistamine drug now withdrawn from	—	280
21	Camptothecin	—	300
22	pictilisib	—	25
23	triolimus [Supplementary Concept]	—	33
24	Idarubicin	—	299
25	Colchicine	—	300
26	Azacitidine	—	298
27	Azacitidine	—	300
28	Methylene Blue	—	200
29	Azathioprine	—	300
30	Mestranol	—	300
31	vinblastine sulfate	—	81
32	chrysin	—	300
33	Hexachlorophene	—	300
34	Chlormadinone Acetate	—	300
35	Nocodazole Nocodazole is	—	215
36	Megestrol Acetate Megestrol acetate is	—	300
37	Nisoldipine	—	297
38	Kaempferols	—	300
39	Dactinomycin	—	297
40	Deslanoside Deacetyllanatoside C.	—	89
41	Melengestrol Acetate	—	300
42	Proscillaridin	—	219
43	Vincristine	—	299
44	Simvastatin	—	1,000
45	Buspirone	—	299
46	Disulfiram	—	297
47	Ethynodiol Diacetate	—	300
48	Levonorgestrel	—	292
49	Medroxyprogesterone Acetate	—	299
50	Mometasone Furoate	—	292

About the Potential therapeutics for SARS Pathway

The Potential therapeutics for SARS pathway is catalogued in Reactome (ID: R-HSA-9679191) and involves 40 genes. In the BiohacksAI corpus, 462 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1.