What compounds affect the RHOBTB GTPase Cycle pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the RHOBTB GTPase Cycle pathway (Reactome ID: R-HSA-9706574). These compounds target 6 genes within this pathway.

What genes are in the RHOBTB GTPase Cycle pathway?

The RHOBTB GTPase Cycle pathway involves 6 genes. Key genes include: CCT2, CDC37, HSP90AA1, HSP90AB1, PDE5A, ROCK2.

RHOBTB GTPase Cycle

REACTOME PATHWAY

Reactome: R-HSA-97065746 genes41 compounds

The RHOBTB GTPase Cycle pathway (Reactome ID: R-HSA-9706574) involves 6 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCT2 CDC37 HSP90AA1 HSP90AB1 PDE5A ROCK2

Compounds Affecting RHOBTB GTPase Cycle

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	celastrol	—	300
3	triolimus [Supplementary Concept]	—	33
4	monorden	—	8
5	gedunin	—	54
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	ag490	—	14
14	Idarubicin	—	299
15	piceatannol	—	300
16	Nitroprusside	—	299
17	2-Chloroadenosine 2-Chloroadenosine.	—	300
18	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
19	Calcimycin	—	216
20	Calcitriol	—	300
21	Ciclopirox	—	88
22	Clotrimazole	—	296
23	cycloheximide	—	300
24	deguelin [Supplementary Concept]	—	151
25	Disulfiram	—	297
26	Hexachlorophene	—	300
27	Indazoles	—	300
28	Miconazole	—	298
29	specioside	—	6
30	Wortmannin	—	300
31	hydroxyfasudil [Supplementary Concept]	—	11
32	kenpaullone	—	8
33	Kinetin	—	300
34	alsterpaullone	—	12
35	Crizotinib	—	298
36	Edaravone	—	298
37	sp600125	—	117
38	Sildenafil Citrate	—	300
39	Epimedium	—	300
40	Papaverine	—	299
41	Methylene Blue	—	200

About the RHOBTB GTPase Cycle Pathway

The RHOBTB GTPase Cycle pathway is catalogued in Reactome (ID: R-HSA-9706574) and involves 6 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCT2, CDC37, HSP90AA1, HSP90AB1, PDE5A.