Nuclear events stimulated by ALK signaling in cancer

Q: What compounds affect the Nuclear events stimulated by ALK signaling in cancer pathway?

60 compounds in the BiohacksAI corpus have documented interactions with genes in the Nuclear events stimulated by ALK signaling in cancer pathway (Reactome ID: R-HSA-9725371). These compounds target 15 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-972537115 genes60 compounds

The Nuclear events stimulated by ALK signaling in cancer pathway (Reactome ID: R-HSA-9725371) involves 15 genes and is affected by 60 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 BCL2A1 CCNB1 CUL1 DNMT1 FOXM1 HDAC1 MAPK1 MAPK3 NPM1 PTPN6 RBX1 STAT3 STAT5A ZAP70

Compounds Affecting Nuclear events stimulated by ALK signaling in cancer

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	plumbagin [Supplementary Concept]	—	300
5	pd98059	—	7
6	fisetin	—	78
7	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
8	trametinib	—	296
9	withaferin	—	300
10	egcg	—	300
11	Celecoxib	—	295
12	ninhydrin	—	300
13	Crizotinib	—	298
14	tyrphostin ag 1478	—	4
15	Clotrimazole	—	296
16	sp600125	—	117
17	Progesterone	—	299
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Benzalkonium Compounds	—	299
20	Calcimycin	—	216
21	daph	—	2
22	Diphenhydramine	—	14
23	ha1004	—	4
24	Lithocholic Acid	—	300
25	Loratadine	—	296
26	trequinsin hydrochloride	—	1
27	s adenosylhomocysteine	—	300
28	Oleic Acid	—	112
29	Anthralin	—	299
30	Azacitidine	—	298
31	Azacitidine	—	300
32	Carboxin	—	174
33	Cefdinir	—	298
34	Cefixime	—	300
35	Decitabine	—	298
36	Fluorometholone	—	299
37	Oxytetracycline	—	300
38	Uridine	—	300
39	Vorinostat	—	299
40	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
41	scriptaid	—	53
42	Valproic Acid	—	296
43	pictilisib	—	25
44	Butyric Acid	—	300
45	Ursolic Acid	—	300
46	Daunorubicin	—	298
47	Bortezomib	—	300
48	Camptothecin	—	300
49	indirubin	—	300
50	Apigenin 5,7,4'-trihydroxy-flavone,	—	300

About the Nuclear events stimulated by ALK signaling in cancer Pathway

The Nuclear events stimulated by ALK signaling in cancer pathway is catalogued in Reactome (ID: R-HSA-9725371) and involves 15 genes. In the BiohacksAI corpus, 60 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, BCL2A1, CCNB1, CUL1, DNMT1.