Regulation of Expression and Function of Type I Classical Cadherins

Q: What compounds affect the Regulation of Expression and Function of Type I Classical Cadherins pathway?

145 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of Expression and Function of Type I Classical Cadherins pathway (Reactome ID: R-HSA-9764274). These compounds target 56 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-976427456 genes145 compounds

The Regulation of Expression and Function of Type I Classical Cadherins pathway (Reactome ID: R-HSA-9764274) involves 56 genes and is affected by 145 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 CSNK2A1 CSNK2A2 CSNK2A3 CSNK2B CTBP1 CTSL EED EZH2 FURIN FYN GANAB HDAC1 HDAC2 KDM1A KMT5A MAPK1 MAPK3 MDM2 MPHOSPH8 MYC PKM PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7+26 more

Compounds Affecting Regulation of Expression and Function of Type I Classical Cadherins

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	fisetin	—	78
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	kenpaullone	—	8
9	Sorafenib	—	300
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	chrysin	—	300
12	alsterpaullone	—	12
13	Kaempferols	—	300
14	Vanillic Acid	—	300
15	Niclosamide	—	299
16	Ursolic Acid	—	300
17	sp600125	—	117
18	Vorinostat	—	299
19	pd98059	—	7
20	tyrphostin ag 1478	—	4
21	ly294002	—	11
22	pictilisib	—	25
23	Calcimycin	—	216
24	Astemizole Antihistamine drug now withdrawn from	—	280
25	Fluspirilene	—	74
26	tyrphostin 9	—	2
27	Methotrexate	—	289
28	Thioridazine	—	35
29	daph	—	2
30	Disulfiram	—	297
31	trequinsin hydrochloride	—	1
32	plumbagin [Supplementary Concept]	—	300
33	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
34	trametinib	—	296
35	withaferin	—	300
36	egcg	—	300
37	Genistein	—	300
38	Dasatinib	—	299
39	Resveratrol	—	298
40	Crizotinib	—	298
41	Suramin	—	300
42	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
43	scriptaid	—	53
44	Valproic Acid	—	296
45	Butyric Acid	—	300
46	Celecoxib	—	295
47	Daunorubicin	—	298
48	Camptothecin	—	300
49	Digoxin	—	299
50	cycloheximide	—	300

About the Regulation of Expression and Function of Type I Classical Cadherins Pathway

The Regulation of Expression and Function of Type I Classical Cadherins pathway is catalogued in Reactome (ID: R-HSA-9764274) and involves 56 genes. In the BiohacksAI corpus, 145 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, CSNK2A1, CSNK2A2, CSNK2A3.