Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Q: What compounds affect the Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway?

43 compounds in the BiohacksAI corpus have documented interactions with genes in the Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway (Reactome ID: R-HSA-983170). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-9831705 genes43 compounds

The Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway (Reactome ID: R-HSA-983170) involves 5 genes and is affected by 43 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HLA-A HLA-B HSPA5 PDIA3 PIK3C3

Compounds Affecting Antigen Presentation: Folding, assembly and peptide loading of class I MHC

#	Compound	Targets Hit	Studies
1	Camptothecin	—	300
2	Ouabain	—	300
3	withaferin	—	300
4	celastrol	—	300
5	Disulfiram	—	297
6	Idarubicin	—	299
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Bortezomib	—	300
10	Calcimycin	—	216
11	Crizotinib	—	298
12	cycloheximide	—	300
13	Dactinomycin	—	297
14	Daunorubicin	—	298
15	Emetine	—	298
16	Epirubicin	—	300
17	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
18	3-(1-(3-hydroxy-4-methoxyphenyl)methylidene)-6-methylchroman-4-one [Supplementary Concept]	—	1
19	kenpaullone	—	8
20	Proscillaridin	—	219
21	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
22	Tripterygium	—	300
23	cbd	—	298
24	Genistein	—	300
25	Sertraline	—	1,000
26	cannabidiol	—	296
27	Deslanoside Deacetyllanatoside C.	—	89
28	Digitoxin	—	300
29	Digoxin	—	299
30	Feprazone	—	63
31	Leflunomide	—	297
32	Nitrendipine	—	299
33	Phenylbutazone	—	300
34	triolimus [Supplementary Concept]	—	33
35	Thapsigargin	—	300
36	Hexachlorophene	—	300
37	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
38	Ergosterol	—	300
39	torin 1	—	10
40	pictilisib	—	25
41	Wortmannin	—	300
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	juglone hydroxylase [Supplementary Concept] catalyzes	—	279

About the Antigen Presentation: Folding, assembly and peptide loading of class I MHC Pathway

The Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway is catalogued in Reactome (ID: R-HSA-983170) and involves 5 genes. In the BiohacksAI corpus, 43 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HLA-A, HLA-B, HSPA5, PDIA3, PIK3C3.