What compounds affect the Ion channel transport pathway?

79 compounds in the BiohacksAI corpus have documented interactions with genes in the Ion channel transport pathway (Reactome ID: R-HSA-983712). These compounds target 39 genes within this pathway.

What genes are in the Ion channel transport pathway?

The Ion channel transport pathway involves 39 genes. Key genes include: ASIC3, ASPH, ATP12A, ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B1, ATP1B2, ATP1B3.

Ion channel transport

REACTOME PATHWAY

Reactome: R-HSA-98371239 genes79 compounds

The Ion channel transport pathway (Reactome ID: R-HSA-983712) involves 39 genes and is affected by 79 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASIC3 ASPH ATP12A ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 ATP2A1 ATP2A2 ATP2A3 ATP4A ATP4B ATP6V1B2 CAMK2B CAMK2D FKBP1B FXYD2 RAF1 RIPK3 RYR1 RYR2 RYR3 SGK1 SGK2 TRPC5 TRPC6 TRPM2+9 more

Compounds Affecting Ion channel transport

#	Compound	Targets Hit	Studies
1	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
2	Digoxin	—	299
3	Ouabain	—	300
4	Digitoxin	—	300
5	Adenosine Triphosphate	—	300
6	sp600125	—	117
7	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
8	Clotrimazole	—	296
9	Econazole	—	299
10	Spermine	—	300
11	cbd	—	298
12	cannabidiol	—	296
13	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
14	Caffeine	—	299
15	Dantrolene Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in	—	298
16	Ryanodine	—	299
17	Arachidonic Acid	—	245
18	Adenosine Monophosphate Adenine nucleotide containing	—	300
19	Miconazole	—	298
20	Sphingosine	—	300
21	Quercetin	—	300
22	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
23	Suramin	—	300
24	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
25	Sorafenib	—	300
26	Vemurafenib	—	298
27	Cimetidine	—	299
28	paxilline	—	42
29	Hyoscyamine	—	296
30	Carvedilol	—	296
31	Propantheline	—	73
32	Methylene Blue	—	200
33	Hexachlorophene	—	300
34	Promazine	—	40
35	Promethazine	—	121
36	propionylpromazine hydrochloride	—	2
37	Thioridazine	—	35
38	triflupromazine hydrochloride	—	12
39	Duloxetine Hydrochloride	—	993
40	Amoxapine	—	259
41	Fluspirilene	—	74
42	NAD	—	300
43	NAD	—	300
44	NAD	—	300
45	Cyclic ADP-Ribose	—	300
46	Adenosine Diphosphate Ribose	—	300
47	O-Acetyl-ADP-Ribose	—	92
48	Colchicine	—	300
49	Cyclic AMP	—	300
50	Cyclic AMP	—	300

About the Ion channel transport Pathway

The Ion channel transport pathway is catalogued in Reactome (ID: R-HSA-983712) and involves 39 genes. In the BiohacksAI corpus, 79 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASIC3, ASPH, ATP12A, ATP1A1, ATP1A2.