What compounds affect the TGFBR3 expression pathway?

195 compounds in the BiohacksAI corpus have documented interactions with genes in the TGFBR3 expression pathway (Reactome ID: R-HSA-9839394). These compounds target 5 genes within this pathway.

What genes are in the TGFBR3 expression pathway?

The TGFBR3 expression pathway involves 5 genes. Key genes include: AGO2, EP300, RARA, RXRA, SMAD3.

TGFBR3 expression

REACTOME PATHWAY

Reactome: R-HSA-98393945 genes195 compounds

The TGFBR3 expression pathway (Reactome ID: R-HSA-9839394) involves 5 genes and is affected by 195 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 EP300 RARA RXRA SMAD3

Compounds Affecting TGFBR3 expression

#	Compound	Targets Hit	Studies
1	Dactinomycin	—	297
2	Ethidium	—	300
3	Rotenone	—	300
4	Flutamide	—	298
5	Disulfiram	—	297
6	Progesterone	—	299
7	cycloheximide	—	300
8	Hexachlorophene	—	300
9	Astemizole Antihistamine drug now withdrawn from	—	280
10	Azacitidine	—	298
11	Azacitidine	—	300
12	Celecoxib	—	295
13	Danazol	—	298
14	Dinitrochlorobenzene	—	300
15	Promethazine	—	121
16	Genistein	—	300
17	Vitamin	—	295
18	Nisoldipine	—	297
19	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
20	Methylene Blue	—	200
21	Testosterone	—	299
22	Colchicine	—	300
23	Dasatinib	—	299
24	Daunorubicin	—	298
25	Emetine	—	298
26	Fluspirilene	—	74
27	Gemfibrozil	—	297
28	Idazoxan	—	300
29	Lynestrenol	—	299
30	Niclosamide	—	299
31	o-Phthalaldehyde	—	300
32	triflupromazine hydrochloride	—	12
33	Vincristine	—	299
34	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
35	chrysin	—	300
36	Fluoxetine	—	1,000
37	Kaempferols	—	300
38	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
39	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
40	Bortezomib	—	300
41	Calcitriol	—	300
42	Cladribine	—	297
43	Dihydrotestosterone	—	300
44	Ethinyl Estradiol	—	300
45	Loratadine	—	296
46	Perphenazine	—	297
47	Piperazine	—	299
48	Podophyllotoxin	—	14
49	Retinaldehyde	—	300
50	Sulfanilamide	—	300

About the TGFBR3 expression Pathway

The TGFBR3 expression pathway is catalogued in Reactome (ID: R-HSA-9839394) and involves 5 genes. In the BiohacksAI corpus, 195 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, EP300, RARA, RXRA, SMAD3.