What genes are in the Regulation of endogenous retroelements pathway?

The Regulation of endogenous retroelements pathway involves 7 genes. Key genes include: EHMT1, EHMT2, HDAC1, HDAC2, MPHOSPH8, SETDB1, SMARCA2.

Regulation of endogenous retroelements

Q: What compounds affect the Regulation of endogenous retroelements pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of endogenous retroelements pathway (Reactome ID: R-HSA-9842860). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98428607 genes48 compounds

The Regulation of endogenous retroelements pathway (Reactome ID: R-HSA-9842860) involves 7 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EHMT1 EHMT2 HDAC1 HDAC2 MPHOSPH8 SETDB1 SMARCA2

Compounds Affecting Regulation of endogenous retroelements

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	s adenosylhomocysteine	—	300
3	Vorinostat	—	299
4	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
5	scriptaid	—	53
6	Valproic Acid	—	296
7	pictilisib	—	25
8	Butyric Acid	—	300
9	Ursolic Acid	—	300
10	Celecoxib	—	295
11	Daunorubicin	—	298
12	Bortezomib	—	300
13	Camptothecin	—	300
14	Glutathione	—	300
15	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
16	Dimethyl Sulfoxide	—	300
17	ninhydrin	—	300
18	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
19	Aurintricarboxylic Acid	—	184
20	Cisplatin	—	300
21	Nitroprusside	—	299
22	Quercetin	—	300
23	Methotrexate	—	289
24	daph	—	2
25	Dequalinium	—	46
26	Diamide	—	300
27	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
28	Fluspirilene	—	74
29	Idarubicin	—	299
30	Iodoacetamide	—	300
31	Levodopa	—	297
32	Methyldopa	—	297
33	Nicardipine	—	94
34	Perphenazine	—	297
35	piceatannol	—	300
36	Promethazine	—	121
37	Reserpine	—	297
38	Thioridazine	—	35
39	trequinsin hydrochloride	—	1
40	tyrphostin 9	—	2
41	Cyproheptadine	—	299
42	Gliotoxin	—	300
43	Genistein	—	300
44	alsterpaullone	—	12
45	calycosin	—	300
46	kenpaullone	—	8
47	chrysin	—	300
48	Lovastatin	—	300

About the Regulation of endogenous retroelements Pathway

The Regulation of endogenous retroelements pathway is catalogued in Reactome (ID: R-HSA-9842860) and involves 7 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EHMT1, EHMT2, HDAC1, HDAC2, MPHOSPH8.