Transcriptional and post-translational regulation of MITF-M expression and activity

Q: What compounds affect the Transcriptional and post-translational regulation of MITF-M expression and activity pathway?

145 compounds in the BiohacksAI corpus have documented interactions with genes in the Transcriptional and post-translational regulation of MITF-M expression and activity pathway (Reactome ID: R-HSA-9856649). These compounds target 25 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-985664925 genes145 compounds

The Transcriptional and post-translational regulation of MITF-M expression and activity pathway (Reactome ID: R-HSA-9856649) involves 25 genes and is affected by 145 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CREB1 CREBBP EDNRB EP300 GSK3B HDAC1 IARS1 KARS1 KIT LARS1 MAPK1 MAPK3 MARK3 MC1R MC3R MC5R MITF RPS6KA1 SIRT1 SUMO1 TFE3 XPO1 YWHAB YWHAG

Compounds Affecting Transcriptional and post-translational regulation of MITF-M expression and activity

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Bortezomib	—	300
3	Nocodazole Nocodazole is	—	215
4	plumbagin [Supplementary Concept]	—	300
5	alsterpaullone	—	12
6	kenpaullone	—	8
7	sp600125	—	117
8	egcg	—	300
9	cycloheximide	—	300
10	Camptothecin	—	300
11	pictilisib	—	25
12	Quercetin	—	300
13	pd98059	—	7
14	fisetin	—	78
15	alpha-MSH	—	300
16	bremelanotide [Supplementary Concept]	—	36
17	melanotan-II [Supplementary Concept] synthetic cyclic heptapeptide,	—	84
18	Cefdinir	—	298
19	Ethidium	—	300
20	Oxytetracycline	—	300
21	Rutin	—	300
22	Oxyphenbutazone	—	300
23	Topotecan	—	300
24	Azacitidine	—	298
25	Azacitidine	—	300
26	Calcimycin	—	216
27	celastrol	—	300
28	Ciclopirox	—	88
29	Demecolcine	—	246
30	torin 1	—	10
31	Vincristine	—	299
32	Vorinostat	—	299
33	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
34	trequinsin hydrochloride	—	1
35	chrysin	—	300
36	Dasatinib	—	299
37	Daunorubicin	—	298
38	Imatinib Mesylate	—	300
39	Masoprocol	—	300
40	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
41	trametinib	—	296
42	withaferin	—	300
43	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
44	Ursolic Acid	—	300
45	hydroxyfasudil [Supplementary Concept]	—	11
46	colchine	—	2
47	Anthralin	—	299
48	Aurintricarboxylic Acid	—	184
49	Biotin	—	297
50	Rolitetracycline	—	166

About the Transcriptional and post-translational regulation of MITF-M expression and activity Pathway

The Transcriptional and post-translational regulation of MITF-M expression and activity pathway is catalogued in Reactome (ID: R-HSA-9856649) and involves 25 genes. In the BiohacksAI corpus, 145 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CREB1, CREBBP, EDNRB, EP300.