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BiohacksAI/Compounds/Berberine/Similar

Compounds Similar to Berberine

10 compounds with shared biological targets · BiohacksAI corpus v20260307-01

The compounds below share molecular targets and biological mechanisms with Berberine, including interactions with ACHE, CYP1B1, CYP2D6. Similarity is calculated using target-weighted Jaccard scoring across the BiohacksAI BindingDB corpus. Higher shared target counts indicate stronger mechanistic overlap.

View Berberine profile →GLUCOSE METABOLISM pathwayINSULIN SIGNALING pathway
Similar Compounds — Ranked by Target Overlap
1
Proguanil
8
shared
299
studies
38%
overlap
2
Metformin
7
shared
1,000
studies
35%
overlap
3
Antimycin
9
shared
300
studies
31%
overlap
4
Fccp
8
shared
76
studies
27%
overlap
5
Adenosine
7
shared
300
studies
24%
overlap
6
Rotenone
12
shared
300
studies
21%
overlap
7
Oleanolic
7
shared
300
studies
18%
overlap
8
Ursolic
10
shared
300
studies
17%
overlap
9
Deguelin
5
shared
151
studies
13%
overlap
10
Niclosamideorganic
12
shared
299
studies
12%
overlap
Shared Biological Targets
PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1ADRA1AHOMOESR1

Click a target to see all compounds with interactions at that molecular target.

Similarity between compounds is computed using IDF-weighted Jaccard scoring across shared molecular targets in the BiohacksAI BindingDB corpus. Compounds with higher overlap scores share more targets, weighted by how specific those targets are across the entire corpus.

Explore related resources: Berberine full profile · Browse all compounds · Biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.