What compounds target ADRA1B?

BiohacksAI has identified 41 compounds that interact with ADRA1B (adrenoceptor alpha 1B). Top compounds include: Phentolamine, Yohimbine, Tamsulosin, Idazoxan, Norepinephrine Precursor of epinephrine that is secreted by. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA1B (adrenoceptor alpha 1B)?

ADRA1B is adrenoceptor alpha 1B. It is a molecular target for 41 compounds documented in PubMed bioassay data. UniProt ID: P35368. NCBI Gene ID: 147.

ADRA1B

MOLECULAR TARGET

adrenoceptor alpha 1B

UniProt: P35368 NCBI Gene: 14741 compounds

ADRA1B (adrenoceptor alpha 1B) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA1B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Phentolamine	3.71	40
2	Yohimbine	3.18	23
3	Tamsulosin	3.14	22
4	Idazoxan	2.94	18
5	Norepinephrine Precursor of epinephrine that is secreted by	2.89	17
6	Clonidine	2.48	11
7	Oxymetazoline	2.30	9
8	Mianserin	2.20	8
9	Buspirone	2.20	8
10	Epinephrine	2.20	8
11	Piperoxan	2.20	8
12	Indoramin	1.95	6
13	Phenylephrine	1.95	6
14	Quetiapine Fumarate	1.79	5
15	Aripiprazole	1.79	5
16	Fluoxetine	1.61	4
17	Naphazoline	1.61	4
18	Dihydroergotamine	1.39	3
19	Tolazoline	1.39	3
20	Carvedilol	1.10	2
21	Dihydroergotamine	1.10	2
22	eliprodil	1.10	2
23	Methoxamine	1.10	2
24	Phenoxybenzamine	1.10	2
25	Platelet Activating Factor	1.10	2
26	Trazodone	1.10	2
27	Amlodipine	0.69	1
28	Losartan	0.69	1
29	amn082	0.69	1
30	Atenolol	0.69	1
31	Cyproheptadine	0.69	1
32	Dexmedetomidine	0.69	1
33	Guanabenz	0.69	1
34	Hydroxyzine	0.69	1
35	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	0.69	1
36	Labetalol	0.69	1
37	Lisuride	0.69	1
38	Loxapine	0.69	1
39	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	0.69	1
40	Metergoline	0.69	1
41	Pergolide	0.69	1

About ADRA1B as a Drug Target

ADRA1B (adrenoceptor alpha 1B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented ADRA1B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA1B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.