What compounds target ADRA1D?

BiohacksAI has identified 40 compounds that interact with ADRA1D (adrenoceptor alpha 1D). Top compounds include: Phentolamine, Yohimbine, Tamsulosin, Norepinephrine Precursor of epinephrine that is secreted by, Idazoxan. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA1D (adrenoceptor alpha 1D)?

ADRA1D is adrenoceptor alpha 1D. It is a molecular target for 40 compounds documented in PubMed bioassay data. UniProt ID: P25100. NCBI Gene ID: 146.

ADRA1D

MOLECULAR TARGET

adrenoceptor alpha 1D

UniProt: P25100 NCBI Gene: 14640 compounds

ADRA1D (adrenoceptor alpha 1D) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA1D

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Phentolamine	3.76	42
2	Yohimbine	3.18	23
3	Tamsulosin	3.14	22
4	Norepinephrine Precursor of epinephrine that is secreted by	3.09	21
5	Idazoxan	2.94	18
6	Clonidine	2.56	12
7	Oxymetazoline	2.48	11
8	Epinephrine	2.30	9
9	Mianserin	2.20	8
10	Buspirone	2.20	8
11	Piperoxan	2.20	8
12	Indoramin	1.95	6
13	Phenylephrine	1.79	5
14	Fluoxetine	1.61	4
15	Quetiapine Fumarate	1.61	4
16	Aripiprazole	1.61	4
17	Naphazoline	1.61	4
18	Dihydroergotamine	1.39	3
19	Methoxamine	1.39	3
20	Tolazoline	1.39	3
21	Carvedilol	1.10	2
22	Dexmedetomidine	1.10	2
23	eliprodil	1.10	2
24	Labetalol	1.10	2
25	Phenoxybenzamine	1.10	2
26	Platelet Activating Factor	1.10	2
27	Trazodone	1.10	2
28	Amlodipine	0.69	1
29	Losartan	0.69	1
30	amn082	0.69	1
31	Atenolol	0.69	1
32	Cyproheptadine	0.69	1
33	Dihydroergotamine	0.69	1
34	Guanabenz	0.69	1
35	Hydroxyzine	0.69	1
36	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	0.69	1
37	Loxapine	0.69	1
38	Metergoline	0.69	1
39	Pergolide	0.69	1
40	Phenylpropanolamine	0.69	1

About ADRA1D as a Drug Target

ADRA1D (adrenoceptor alpha 1D) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented ADRA1D interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA1D inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.