What compounds target CHRM1?

BiohacksAI has identified 130 compounds that interact with CHRM1 (cholinergic receptor muscarinic 1). Top compounds include: Hyoscyamine, Arecoline, Pilocarpine, N-Methylscopolamine, Scopolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHRM1 (cholinergic receptor muscarinic)?

CHRM1 is cholinergic receptor muscarinic 1. It is a molecular target for 130 compounds documented in PubMed bioassay data. UniProt ID: P11229. NCBI Gene ID: 1128.

CHRM1

MOLECULAR TARGET

cholinergic receptor muscarinic 1

UniProt: P11229 NCBI Gene: 1128130 compounds

CHRM1 (cholinergic receptor muscarinic 1) is targeted by 130 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHRM1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Hyoscyamine	4.41	81
2	Arecoline	4.06	57
3	Pilocarpine	3.69	39
4	N-Methylscopolamine	3.00	19
5	Scopolamine	2.83	16
6	Quetiapine Fumarate	2.56	12
7	Amoxapine	2.56	12
8	Loratadine	2.56	12
9	Astemizole Antihistamine drug now withdrawn from	2.48	11
10	Muscarine	2.48	11
11	Chlorhexidine	2.40	10
12	doxylamine succinate	2.40	10
13	Ethidium	2.20	8
14	Maprotiline	2.20	8
15	Promethazine	2.20	8
16	Testosterone Propionate	2.20	8
17	Diphenhydramine	2.08	7
18	Propantheline	2.08	7
19	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.95	6
20	Cyproheptadine	1.95	6
21	Hyoscyamine	1.95	6
22	Perphenazine	1.95	6
23	Promazine	1.95	6
24	Promethazine	1.95	6
25	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	1.95	6
26	Thioridazine	1.95	6
27	Progesterone	1.79	5
28	Butylscopolammonium Bromide Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of	1.79	5
29	Loxapine	1.79	5
30	mg624	1.79	5
31	Nicergoline	1.79	5
32	Acetaldehyde	1.61	4
33	Aripiprazole	1.61	4
34	rhinopront syrup [Supplementary Concept] contains 300 mg phenylpropanolamine and 24 mg carbinoxamine per 100 g, both chemically adsorbed on	1.61	4
35	Cetylpyridinium Cationic bactericidal surfactant used as	1.61	4
36	Clotrimazole	1.61	4
37	dilazep	1.61	4
38	Dimenhydrinate	1.61	4
39	dofetilide	1.61	4
40	Doxazosin	1.61	4
41	eliprodil	1.61	4
42	Flunarizine Flunarizine is	1.61	4
43	Nicardipine	1.61	4
44	Nortriptyline	1.61	4
45	o-Phthalaldehyde	1.61	4
46	Polidocanol	1.61	4
47	triflupromazine hydrochloride	1.61	4
48	Cinnarizine	1.39	3
49	Dequalinium	1.39	3
50	Ethoxyquin Antioxidant; also	1.39	3

Showing top 50 of 130 compounds. Use the BiohacksAI search to explore all CHRM1 modulators.

About CHRM1 as a Drug Target

CHRM1 (cholinergic receptor muscarinic 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 130 compounds with documented CHRM1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHRM1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.