What compounds target CHRM5?

BiohacksAI has identified 45 compounds that interact with CHRM5 (cholinergic receptor muscarinic 5). Top compounds include: Hyoscyamine, Arecoline, Pilocarpine, N-Methylscopolamine, Hyoscyamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CHRM5 (cholinergic receptor muscarinic)?

CHRM5 is cholinergic receptor muscarinic 5. It is a molecular target for 45 compounds documented in PubMed bioassay data. UniProt ID: P08912. NCBI Gene ID: 1133.

CHRM5

MOLECULAR TARGET

cholinergic receptor muscarinic 5

UniProt: P08912 NCBI Gene: 113345 compounds

CHRM5 (cholinergic receptor muscarinic 5) is targeted by 45 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CHRM5

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Hyoscyamine	4.09	59
2	Arecoline	3.61	36
3	Pilocarpine	2.89	17
4	N-Methylscopolamine	2.48	11
5	Hyoscyamine	1.95	6
6	Scopolamine	1.95	6
7	Muscarine	1.61	4
8	hexahydrosiladiphenidol	1.39	3
9	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
10	Fluoxetine	0.69	1
11	Mianserin	0.69	1
12	Quetiapine Fumarate	0.69	1
13	Ascorbic Acid	0.69	1
14	Amoxapine	0.69	1
15	Ascorbic Acid	0.69	1
16	Bisphenol A-Glycidyl Methacrylate	0.69	1
17	Butaclamol	0.69	1
18	Butylscopolammonium Bromide Antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of	0.69	1
19	Chlorpheniramine	0.69	1
20	chlorprothixene hydrochloride	0.69	1
21	Cyclizine	0.69	1
22	Cyproheptadine	0.69	1
23	Dimethindene	0.69	1
24	Diphenhydramine	0.69	1
25	Guanabenz	0.69	1
26	Ipratropium	0.69	1
27	Loxapine	0.69	1
28	Loxapine	0.69	1
29	Maprotiline	0.69	1
30	mg624	0.69	1
31	Nicorandil	0.69	1
32	Nortriptyline	0.69	1
33	Nortriptyline	0.69	1
34	Perphenazine	0.69	1
35	Promazine	0.69	1
36	Promethazine	0.69	1
37	Propantheline	0.69	1
38	propionylpromazine hydrochloride	0.69	1
39	Salicylic Acid	0.69	1
40	Strychnine	0.69	1
41	Thioridazine	0.69	1
42	Tilorone	0.69	1
43	Tolterodine Tartrate	0.69	1
44	Triamcinolone	0.69	1
45	triflupromazine hydrochloride	0.69	1

About CHRM5 as a Drug Target

CHRM5 (cholinergic receptor muscarinic 5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 45 compounds with documented CHRM5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CHRM5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.