What compounds target DRD4?

BiohacksAI has identified 34 compounds that interact with DRD4 (dopamine receptor D4). Top compounds include: Aripiprazole, Pramipexole, Loxapine, Pergolide, Raclopride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DRD4 (dopamine receptor D4)?

DRD4 is dopamine receptor D4. It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: P21917. NCBI Gene ID: 1815.

DRD4

MOLECULAR TARGET

dopamine receptor D4

UniProt: P21917 NCBI Gene: 181534 compounds

DRD4 (dopamine receptor D4) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DRD4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Aripiprazole	3.00	19
2	Pramipexole	2.56	12
3	Loxapine	1.95	6
4	Pergolide	1.95	6
5	Raclopride	1.79	5
6	Quetiapine Fumarate	1.61	4
7	Butaclamol	1.61	4
8	Mianserin	1.39	3
9	Bromocriptine	1.39	3
10	Lisuride	1.39	3
11	Amoxapine	1.10	2
12	Cabergoline	1.10	2
13	Dihydroergotamine	1.10	2
14	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.10	2
15	Pindolol	1.10	2
16	Sulpiride	1.10	2
17	Tetrahydropapaveroline	1.10	2
18	Quercetin	0.69	1
19	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
20	Astemizole Antihistamine drug now withdrawn from	0.69	1
21	Buspirone	0.69	1
22	Carvedilol	0.69	1
23	Cyproheptadine	0.69	1
24	Fentanyl	0.69	1
25	Hydroxyzine	0.69	1
26	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	0.69	1
27	Meclizine	0.69	1
28	Metergoline	0.69	1
29	Metoclopramide	0.69	1
30	nafadotride	0.69	1
31	Piribedil	0.69	1
32	Promethazine	0.69	1
33	Trazodone	0.69	1
34	Yohimbine	0.69	1

About DRD4 as a Drug Target

DRD4 (dopamine receptor D4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented DRD4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DRD4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.