What compounds target HTR1D?

BiohacksAI has identified 30 compounds that interact with HTR1D (5-hydroxytryptamine receptor 1D). Top compounds include: Sumatriptan, Metergoline, Yohimbine, Ergotamine, Mianserin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR1D (5-hydroxytryptamine receptor 1D)?

HTR1D is 5-hydroxytryptamine receptor 1D. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: P28565. NCBI Gene ID: 25323.

HTR1D

MOLECULAR TARGET

5-hydroxytryptamine receptor 1D

UniProt: P28565 NCBI Gene: 2532330 compounds

HTR1D (5-hydroxytryptamine receptor 1D) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR1D

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Sumatriptan	3.74	41
2	Metergoline	2.20	8
3	Yohimbine	2.20	8
4	Ergotamine	1.95	6
5	Mianserin	1.61	4
6	Methysergide	1.61	4
7	Bufotenin	1.39	3
8	Dihydroergotamine	1.39	3
9	Oxymetazoline	1.39	3
10	Pergolide	1.39	3
11	Aripiprazole	1.10	2
12	Fluspirilene	1.10	2
13	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.10	2
14	Mescaline Hallucinogenic alkaloid isolated from	1.10	2
15	Pindolol	1.10	2
16	Platelet Activating Factor	1.10	2
17	Fluoxetine	0.69	1
18	Quetiapine Fumarate	0.69	1
19	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
20	brl 15572	0.69	1
21	Bromocriptine	0.69	1
22	Cabergoline	0.69	1
23	Cyproheptadine	0.69	1
24	Dihydroergotamine	0.69	1
25	Lisuride	0.69	1
26	Metoclopramide	0.69	1
27	Nortriptyline	0.69	1
28	Quipazine	0.69	1
29	Tamsulosin	0.69	1
30	Vortioxetine	0.69	1

About HTR1D as a Drug Target

HTR1D (5-hydroxytryptamine receptor 1D) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented HTR1D interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR1D inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.