Question 1

What compounds target HTR5A?

Accepted Answer

BiohacksAI has identified 27 compounds that interact with HTR5A (5-hydroxytryptamine receptor 5A). Top compounds include: Ergotamine, Sumatriptan, Methysergide, Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is, Yohimbine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is HTR5A (5-hydroxytryptamine receptor 5A)?

Accepted Answer

HTR5A is 5-hydroxytryptamine receptor 5A. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: P35364. NCBI Gene ID: 25689.

#	Compound	Confidence	Active Assays
1	Ergotamine	2.48	11
2	Sumatriptan	2.08	7
3	Methysergide	1.61	4
4	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.39	3
5	Yohimbine	1.39	3
6	Bufotenin	1.10	2
7	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
8	Dihydroergotamine	1.10	2
9	Mescaline Hallucinogenic alkaloid isolated from	1.10	2
10	Metergoline	1.10	2
11	Pergolide	1.10	2
12	Pindolol	1.10	2
13	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
14	Amoxapine	0.69	1
15	Aripiprazole	0.69	1
16	Astemizole Antihistamine drug now withdrawn from	0.69	1
17	Cyproheptadine	0.69	1
18	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
19	Digoxin	0.69	1
20	Dihydroergotoxine	0.69	1
21	Hydroxyzine	0.69	1
22	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
23	Lisuride	0.69	1
24	Loxapine	0.69	1
25	Nortriptyline	0.69	1
26	Sorafenib	0.69	1
27	Vortioxetine	0.69	1

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HTR5A

Compounds Targeting HTR5A

About HTR5A as a Drug Target