What compounds target SLC6A2?

BiohacksAI has identified 64 compounds that interact with SLC6A2 (solute carrier family 6 member 2). Top compounds include: Duloxetine Hydrochloride, Fluoxetine, protriptyline, Venlafaxine Hydrochloride, Venlafaxine Hydrochloride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SLC6A2 (solute carrier family)?

SLC6A2 is solute carrier family 6 member 2. It is a molecular target for 64 compounds documented in PubMed bioassay data. UniProt ID: P23975. NCBI Gene ID: 6530.

SLC6A2

MOLECULAR TARGET

solute carrier family 6 member 2

UniProt: P23975 NCBI Gene: 653064 compounds

SLC6A2 (solute carrier family 6 member 2) is targeted by 64 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SLC6A2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Duloxetine Hydrochloride	3.26	25
2	Fluoxetine	3.09	21
3	protriptyline	3.00	19
4	Venlafaxine Hydrochloride	2.64	13
5	Venlafaxine Hydrochloride	2.20	8
6	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.79	5
7	Sertraline	1.61	4
8	Maprotiline	1.61	4
9	Mianserin	1.39	3
10	Cyproheptadine	1.39	3
11	Nortriptyline	1.39	3
12	Reboxetine	1.39	3
13	Viloxazine	1.39	3
14	Amoxapine	1.10	2
15	Aripiprazole	1.10	2
16	Astemizole Antihistamine drug now withdrawn from	1.10	2
17	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
18	Desogestrel	1.10	2
19	Ethinyl Estradiol	1.10	2
20	Loxapine	1.10	2
21	Metergoline	1.10	2
22	Milnacipran	1.10	2
23	Nortriptyline	1.10	2
24	Ritodrine	1.10	2
25	Thiethylperazine	1.10	2
26	Amlodipine	0.69	1
27	Quetiapine Fumarate	0.69	1
28	Simvastatin	0.69	1
29	3-Iodobenzylguanidine	0.69	1
30	amn082	0.69	1
31	Aprindine	0.69	1
32	Benzydamine	0.69	1
33	Cabergoline	0.69	1
34	Carvedilol	0.69	1
35	Caspofungin	0.69	1
36	Chlorhexidine	0.69	1
37	Chlorpheniramine	0.69	1
38	cinacalcet	0.69	1
39	Cinnarizine	0.69	1
40	Crizotinib	0.69	1
41	Dequalinium	0.69	1
42	Flunarizine Flunarizine is	0.69	1
43	Fluspirilene	0.69	1
44	Gabexate	0.69	1
45	Guanabenz	0.69	1
46	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
47	Hexachlorophene	0.69	1
48	Idarubicin	0.69	1
49	Labetalol	0.69	1
50	Leflunomide	0.69	1

Showing top 50 of 64 compounds. Use the BiohacksAI search to explore all SLC6A2 modulators.

About SLC6A2 as a Drug Target

SLC6A2 (solute carrier family 6 member 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 64 compounds with documented SLC6A2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SLC6A2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.