Natural NF-κB Inhibitors — Evidence-Based Compounds
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is the master transcription factor of inflammation — controlling expression of cytokines, chemokines, and immune response genes.
NF-κB is chronically activated in most inflammatory diseases, cancer, and aging. It drives expression of TNF-α, IL-6, IL-1β, COX-2, and hundreds of other pro-inflammatory mediators. Natural compounds that inhibit NF-κB activation represent one of the most clinically validated approaches to reducing chronic inflammation. The following are ranked by evidence from the BiohacksAI corpus.
Rankings based on BiohacksAI discovery score, target match with NFKB1, RELA, NFKBIA, pathway overlap, and PubMed study count. All data is deterministic and corpus-verified. Not medical advice.
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Data: PubMed/NCBI, BindingDB, Reactome. © Organiq Sweden AB · Patent pending EVE-PAT-2026-001