What compounds affect the Signaling by NODAL pathway?

86 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by NODAL pathway (Reactome ID: R-HSA-1181150). These compounds target 9 genes within this pathway.

What genes are in the Signaling by NODAL pathway?

The Signaling by NODAL pathway involves 9 genes. Key genes include: ACVR1B, ACVR2A, ACVR2B, FOXO3, FURIN, MAPK1, MAPK3, SMAD2, SMAD3.

Signaling by NODAL

REACTOME PATHWAY

Reactome: R-HSA-11811509 genes86 compounds

The Signaling by NODAL pathway (Reactome ID: R-HSA-1181150) involves 9 genes and is affected by 86 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACVR1B ACVR2A ACVR2B FOXO3 FURIN MAPK1 MAPK3 SMAD2 SMAD3

Compounds Affecting Signaling by NODAL

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	alsterpaullone	—	12
3	kenpaullone	—	8
4	Loratadine	—	296
5	trequinsin hydrochloride	—	1
6	Calcimycin	—	216
7	cycloheximide	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Disulfiram	—	297
11	Nisoldipine	—	297
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Kaempferols	—	300
14	Quercetin	—	300
15	Colchicine	—	300
16	Dactinomycin	—	297
17	Danazol	—	298
18	Dinitrochlorobenzene	—	300
19	Ethidium	—	300
20	Flutamide	—	298
21	Oxyphenbutazone	—	300
22	Podophyllotoxin	—	14
23	vinblastine sulfate	—	81
24	Vincristine	—	299
25	chrysin	—	300
26	egcg	—	300
27	Fluoxetine	—	1,000
28	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Bortezomib	—	300
31	Celecoxib	—	295
32	Ciclopirox	—	88
33	Cladribine	—	297
34	Daunorubicin	—	298
35	Domperidone	—	299
36	Emetine	—	298
37	Equilin	—	216
38	Ethinyl Estradiol	—	300
39	Ezetimibe	—	296
40	Idazoxan	—	300
41	Lynestrenol	—	299
42	Nocodazole Nocodazole is	—	215
43	Masoprocol	—	300
44	o-Phthalaldehyde	—	300
45	Perphenazine	—	297
46	pivampicillin	—	275
47	Promethazine	—	121
48	Rotenone	—	300
49	Salmeterol Xinafoate	—	227
50	Sulbactam	—	299

About the Signaling by NODAL Pathway

The Signaling by NODAL pathway is catalogued in Reactome (ID: R-HSA-1181150) and involves 9 genes. In the BiohacksAI corpus, 86 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACVR1B, ACVR2A, ACVR2B, FOXO3, FURIN.