What compounds affect the Signaling by ERBB2 pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by ERBB2 pathway (Reactome ID: R-HSA-1227986). These compounds target 15 genes within this pathway.

What genes are in the Signaling by ERBB2 pathway?

The Signaling by ERBB2 pathway involves 15 genes. Key genes include: AKT3, CDC37, EGFR, ERBB2, ERBB3, ERBB4, FYN, GRB2, HSP90AA1, MATK.

Signaling by ERBB2

REACTOME PATHWAY

Reactome: R-HSA-122798615 genes62 compounds

The Signaling by ERBB2 pathway (Reactome ID: R-HSA-1227986) involves 15 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CDC37 EGFR ERBB2 ERBB3 ERBB4 FYN GRB2 HSP90AA1 MATK PIK3R1 PTK6 SRC USP8 YES1

Compounds Affecting Signaling by ERBB2

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	tyrphostin ag 1478	—	4
3	Quercetin	—	300
4	Afatinib	—	297
5	celastrol	—	300
6	Crizotinib	—	298
7	Sorafenib	—	300
8	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
9	monorden	—	8
10	ag490	—	14
11	Wortmannin	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	pictilisib	—	25
14	Vemurafenib	—	298
15	kenpaullone	—	8
16	sp600125	—	117
17	triolimus [Supplementary Concept]	—	33
18	gedunin	—	54
19	Novobiocin	—	300
20	caffeic acid	—	300
21	Masoprocol	—	300
22	Tetracycline	—	300
23	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
24	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
25	2-Chloroadenosine 2-Chloroadenosine.	—	300
26	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
27	Calcimycin	—	216
28	Calcitriol	—	300
29	Ciclopirox	—	88
30	Clotrimazole	—	296
31	cycloheximide	—	300
32	deguelin [Supplementary Concept]	—	151
33	Disulfiram	—	297
34	Hexachlorophene	—	300
35	Idarubicin	—	299
36	Indazoles	—	300
37	Miconazole	—	298
38	piceatannol	—	300
39	Nitroprusside	—	299
40	specioside	—	6
41	Axitinib	—	298
42	Kaempferols	—	300
43	Cladribine	—	297
44	Pioglitazone	—	297
45	Resveratrol	—	298
46	Adenosine Monophosphate Adenine nucleotide containing	—	300
47	alsterpaullone	—	12
48	Niclosamide	—	299
49	Rosmarinic Acid	—	300
50	Genistein	—	300

About the Signaling by ERBB2 Pathway

The Signaling by ERBB2 pathway is catalogued in Reactome (ID: R-HSA-1227986) and involves 15 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CDC37, EGFR, ERBB2, ERBB3.