What compounds affect the Developmental Biology pathway?

725 compounds in the BiohacksAI corpus have documented interactions with genes in the Developmental Biology pathway (Reactome ID: R-HSA-1266738). These compounds target 281 genes within this pathway.

What genes are in the Developmental Biology pathway?

The Developmental Biology pathway involves 281 genes. Key genes include: ABCG2, ABL1, ABL2, ACVR1B, ACVR2A, ACVR2B, ADAM10, ADRM1, AGO2, AICDA.

Developmental Biology

REACTOME PATHWAY

Reactome: R-HSA-1266738281 genes725 compounds

The Developmental Biology pathway (Reactome ID: R-HSA-1266738) involves 281 genes and is affected by 725 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCG2 ABL1 ABL2 ACVR1B ACVR2A ACVR2B ADAM10 ADRM1 AGO2 AICDA AKT3 ALDH1A1 ANXA2 APH1A APH1B ARHGAP35 ASH2L ATP6V1B2 BCL2A1 BRCA1 BUB1B-PAK6 CA2 CACNA1C CACNA1D CACNA1G CACNA1H CACNA1I CACNA1S CAPN1 CARM1+251 more

Compounds Affecting Developmental Biology

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Dasatinib	—	299
3	Sorafenib	—	300
4	Quercetin	—	300
5	Nocodazole Nocodazole is	—	215
6	Crizotinib	—	298
7	vinblastine sulfate	—	81
8	Colchicine	—	300
9	Podophyllotoxin	—	14
10	Hexachlorophene	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Vorinostat	—	299
13	Vincristine	—	299
14	alsterpaullone	—	12
15	cycloheximide	—	300
16	sp600125	—	117
17	kenpaullone	—	8
18	Ethidium	—	300
19	Reserpine	—	297
20	chrysin	—	300
21	Demecolcine	—	246
22	Disulfiram	—	297
23	egcg	—	300
24	Kaempferols	—	300
25	Axitinib	—	298
26	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
27	Astemizole Antihistamine drug now withdrawn from	—	280
28	Daunorubicin	—	298
29	Methylene Blue	—	200
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Noscapine	—	300
32	Anisomycin	—	247
33	Resveratrol	—	298
34	Genistein	—	300
35	Progesterone	—	299
36	Nisoldipine	—	297
37	Azacitidine	—	298
38	Azacitidine	—	300
39	pictilisib	—	25
40	Maytansine	—	300
41	Dactinomycin	—	297
42	Digoxin	—	299
43	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
44	tyrphostin ag 1478	—	4
45	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
46	Niclosamide	—	299
47	Celecoxib	—	295
48	Clotrimazole	—	296
49	Afatinib	—	297
50	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300

About the Developmental Biology Pathway

The Developmental Biology pathway is catalogued in Reactome (ID: R-HSA-1266738) and involves 281 genes. In the BiohacksAI corpus, 725 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCG2, ABL1, ABL2, ACVR1B, ACVR2A.