What compounds affect the Signaling by SCF-KIT pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by SCF-KIT pathway (Reactome ID: R-HSA-1433557). These compounds target 19 genes within this pathway.

What genes are in the Signaling by SCF-KIT pathway?

The Signaling by SCF-KIT pathway involves 19 genes. Key genes include: CHEK1, CMA1, FER, FES, FYN, GRB2, JAK2, KIT, LCK, LYN.

Signaling by SCF-KIT

REACTOME PATHWAY

Reactome: R-HSA-143355719 genes56 compounds

The Signaling by SCF-KIT pathway (Reactome ID: R-HSA-1433557) involves 19 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CHEK1 CMA1 FER FES FYN GRB2 JAK2 KIT LCK LYN PIK3R1 PIK3R2 PIK3R3 PTPN6 SRC STAT1 STAT3 STAT5A YES1

Compounds Affecting Signaling by SCF-KIT

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	Crizotinib	—	298
3	Sorafenib	—	300
4	sp600125	—	117
5	tyrphostin ag 1478	—	4
6	kenpaullone	—	8
7	Quercetin	—	300
8	Axitinib	—	298
9	pictilisib	—	25
10	Sirolimus	—	300
11	Cladribine	—	297
12	Methylene Blue	—	200
13	streptonigrin	—	299
14	Afatinib	—	297
15	alsterpaullone	—	12
16	Niclosamide	—	299
17	Acetic Acid Product of	—	300
18	egcg	—	300
19	ly294002	—	11
20	Azauridine	—	300
21	2-Methoxyestradiol	—	300
22	Astemizole Antihistamine drug now withdrawn from	—	280
23	Azathioprine	—	300
24	Calcitriol	—	300
25	Camptothecin	—	300
26	Cytarabine	—	297
27	dihydrorotenone	—	13
28	Podophyllotoxin	—	14
29	Trifluridine	—	295
30	Tripterygium	—	300
31	Kaempferols	—	300
32	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
33	Pioglitazone	—	297
34	Vemurafenib	—	298
35	Resveratrol	—	298
36	Adenosine Monophosphate Adenine nucleotide containing	—	300
37	monorden	—	8
38	piceatannol	—	300
39	Swainsonine	—	300
40	Rosmarinic Acid	—	300
41	Genistein	—	300
42	Avapritinib	—	246
43	Imatinib Mesylate	—	300
44	pd98059	—	7
45	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
46	Wortmannin	—	300
47	alpelisib	—	227
48	torin 1	—	10
49	Budesonide	—	1,000
50	Flurandrenolone	—	65

About the Signaling by SCF-KIT Pathway

The Signaling by SCF-KIT pathway is catalogued in Reactome (ID: R-HSA-1433557) and involves 19 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CHEK1, CMA1, FER, FES, FYN.