What genes are in the Cytosolic sensors of pathogen-associated DNA pathway?

The Cytosolic sensors of pathogen-associated DNA pathway involves 13 genes. Key genes include: CGAS, CHUK, CREBBP, EP300, IKBKB, NFKB1, NFKB2, NFKBIA, PRKDC, RELA.

Cytosolic sensors of pathogen-associated DNA

Q: What compounds affect the Cytosolic sensors of pathogen-associated DNA pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the Cytosolic sensors of pathogen-associated DNA pathway (Reactome ID: R-HSA-1834949). These compounds target 13 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-183494913 genes68 compounds

The Cytosolic sensors of pathogen-associated DNA pathway (Reactome ID: R-HSA-1834949) involves 13 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CGAS CHUK CREBBP EP300 IKBKB NFKB1 NFKB2 NFKBIA PRKDC RELA RIPK3 TBK1 TLR3

Compounds Affecting Cytosolic sensors of pathogen-associated DNA

#	Compound	Targets Hit	Studies
1	chicoric acid	—	117
2	Quercetin	—	300
3	Resveratrol	—	298
4	Bortezomib	—	300
5	Podophyllotoxin	—	14
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	egcg	—	300
8	Kaempferols	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Rutin	—	300
11	Withania	—	500
12	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
13	tamarixetin	—	26
14	withaferin	—	300
15	Disulfiram	—	297
16	Hexachlorophene	—	300
17	Trifluridine	—	295
18	plumbagin [Supplementary Concept]	—	300
19	vinblastine sulfate	—	81
20	Aurintricarboxylic Acid	—	184
21	amlexanox	—	96
22	Crizotinib	—	298
23	Hydrocortisone	—	299
24	Cerulenin	—	300
25	Chlorpropamide	—	300
26	daph	—	2
27	Hydrocortisone	—	298
28	Lovastatin	—	300
29	ly294002	—	11
30	Promethazine	—	121
31	protriptyline	—	296
32	streptonigrin	—	299
33	Sulfaphenazole	—	300
34	Triamcinolone	—	300
35	tyrphostin 1	—	1
36	tyrphostin ag 1478	—	4
37	Voriconazole	—	299
38	Cathelicidins Antimicrobial cationic peptides with	—	300
39	Ursolic Acid	—	300
40	Oleanolic Acid	—	300
41	pyrrolidine dithiocarbamate	—	275
42	Suramin	—	300
43	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
44	Idarubicin	—	299
45	Epirubicin	—	300
46	Daunorubicin	—	298
47	Nisoldipine	—	297
48	Dequalinium	—	136
49	Folic Acid	—	296
50	piromidic acid	—	64

About the Cytosolic sensors of pathogen-associated DNA Pathway

The Cytosolic sensors of pathogen-associated DNA pathway is catalogued in Reactome (ID: R-HSA-1834949) and involves 13 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CGAS, CHUK, CREBBP, EP300, IKBKB.