What compounds affect the Xenobiotics pathway?

621 compounds in the BiohacksAI corpus have documented interactions with genes in the Xenobiotics pathway (Reactome ID: R-HSA-211981). These compounds target 18 genes within this pathway.

What genes are in the Xenobiotics pathway?

The Xenobiotics pathway involves 18 genes. Key genes include: AHR, ARNT, CYP1A1, CYP1A2, CYP2A13, CYP2A6, CYP2B6, CYP2C19, CYP2C8, CYP2C9.

Xenobiotics

REACTOME PATHWAY

Reactome: R-HSA-21198118 genes621 compounds

The Xenobiotics pathway (Reactome ID: R-HSA-211981) involves 18 genes and is affected by 621 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHR ARNT CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2J2 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P

Compounds Affecting Xenobiotics

#	Compound	Targets Hit	Studies
1	Methoxsalen	—	300
2	Ritonavir	—	298
3	Clotrimazole	—	296
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Miconazole	—	298
6	Voriconazole	—	299
7	cbd	—	298
8	cannabidiol	—	296
9	Disulfiram	—	297
10	Quercetin	—	300
11	Ethinyl Estradiol	—	300
12	Carbaryl	—	300
13	Vitamin K 3	—	300
14	Nisoldipine	—	297
15	Pueraria	—	300
16	Kaempferols	—	300
17	Methylene Blue	—	200
18	Danazol	—	298
19	Ethidium	—	300
20	Phenelzine	—	2
21	Piperonyl Butoxide	—	300
22	amlexanox	—	96
23	Axitinib	—	298
24	Edaravone	—	298
25	Reserpine	—	297
26	Isoniazid Antibacterial agent used primarily as	—	299
27	Flutamide	—	298
28	Chlorhexidine	—	299
29	Ethoxyquin Antioxidant; also	—	180
30	Piribedil	—	300
31	Tolazamide	—	169
32	Mestranol	—	300
33	Sulindac	—	297
34	chrysin	—	300
35	Melatonin	—	297
36	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
37	Leflunomide	—	297
38	Melphalan	—	300
39	Podophyllotoxin	—	14
40	Propanil	—	293
41	Fluvoxamine	—	297
42	Amoxapine	—	259
43	Lumefantrine	—	299
44	Nialamide	—	300
45	Simvastatin	—	1,000
46	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
47	Quinidine	—	298
48	Niclosamide	—	299
49	Rotenone	—	300
50	Loratadine	—	296

About the Xenobiotics Pathway

The Xenobiotics pathway is catalogued in Reactome (ID: R-HSA-211981) and involves 18 genes. In the BiohacksAI corpus, 621 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHR, ARNT, CYP1A1, CYP1A2, CYP2A13.