What compounds affect the Selenoamino acid metabolism pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the Selenoamino acid metabolism pathway (Reactome ID: R-HSA-2408522). These compounds target 13 genes within this pathway.

What genes are in the Selenoamino acid metabolism pathway?

The Selenoamino acid metabolism pathway involves 13 genes. Key genes include: AHCY, CBS, CTH, GNMT, GSR, HNMT, IARS1, INMT, KARS1, LARS1.

Selenoamino acid metabolism

REACTOME PATHWAY

Reactome: R-HSA-240852213 genes49 compounds

The Selenoamino acid metabolism pathway (Reactome ID: R-HSA-2408522) involves 13 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AHCY CBS CTH GNMT GSR HNMT IARS1 INMT KARS1 LARS1 LOC102724560 NNMT RPSA

Compounds Affecting Selenoamino acid metabolism

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
3	Crizotinib	—	298
4	Calcimycin	—	216
5	Dequalinium	—	136
6	Ticagrelor	—	299
7	tyrphostin ag 1478	—	4
8	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
9	Chlorhexidine	—	299
10	Cisplatin	—	300
11	darapladib [Supplementary Concept]	—	44
12	Dasatinib	—	299
13	Demeclocycline	—	297
14	Iodoacetamide	—	300
15	pictilisib	—	25
16	Vemurafenib	—	298
17	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
18	Thyroxine	—	994
19	Quercetin	—	300
20	2-Methoxyestradiol	—	300
21	Afatinib	—	297
22	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
23	Disulfiram	—	297
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
25	Estrone	—	300
26	Guanabenz	—	298
27	Methyldopa	—	297
28	Methylergonovine	—	193
29	Methysergide	—	300
30	piceatannol	—	300
31	propionylpromazine hydrochloride	—	2
32	scriptaid	—	53
33	Suramin	—	300
34	Thiorphan	—	300
35	Thyroxine	—	300
36	Triiodothyronine	—	300
37	tyrphostin 9	—	2
38	s adenosylhomocysteine	—	300
39	same	—	299
40	6-Aminonicotinamide	—	300
41	s adenosylmethionine	—	300
42	Methylene Blue	—	200
43	Carmustine	—	297
44	Meloxicam	—	299
45	Adenosine	—	298
46	egcg	—	300
47	Sirolimus	—	300
48	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
49	Mupirocin	—	299

About the Selenoamino acid metabolism Pathway

The Selenoamino acid metabolism pathway is catalogued in Reactome (ID: R-HSA-2408522) and involves 13 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AHCY, CBS, CTH, GNMT, GSR.